SCHEMBL4736268

SCHEMBL4736268

Cc1cccc(Cc2cc3ccc(C(=O)NO)cc3[nH]2)c1

nearest known ligand 0.50

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 9/20 0.50
HDAC8 Q9BY41 4/20 0.50
ITK Q08881 2/20 0.46
CCNC P24863 1/20 0.46
CDK8 P49336 1/20 0.46
KDM5B Q9UGL1 1/20 0.45
HDAC1 Q13547 3/20 0.43
HDAC3 O15379 2/20 0.41
DAO P14920 1/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
TAAR1 Q96RJ0 1/20 0.40
DRD4 P21917 1/20 0.39
HDAC7 Q8WUI4 1/20 0.39
HDAC9 Q9UKV0 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5129029 0.86 ITK (0.56) HDAC6HDAC8ITKHDAC1HDAC3
SCHEMBL4734211 0.86 HDAC1 (0.52) HDAC6ITKHDAC1HDAC3DAO
SCHEMBL4735968 0.86 HDAC6 (0.50) HDAC6HDAC8ITKHDAC1HDAC3
SCHEMBL4735903 0.85 HDAC1 (0.55) HDAC6HDAC8ITKKDM5BHDAC1
SCHEMBL4796231 0.83 HDAC6 (0.54) HDAC6HDAC8ITKHDAC1HDAC3
SCHEMBL5132974 0.80 MAPT (0.44) HDAC6HDAC8ITKHDAC1HDAC3
SCHEMBL5131169 0.80 HDAC6 (0.51) HDAC6HDAC8ITKKDM5BHDAC1
SCHEMBL4737672 0.79 HDAC8 (0.47) HDAC6HDAC8ITKHDAC1HDAC3
SCHEMBL5132984 0.79 HDAC6 (0.51) HDAC6HDAC8ITKHDAC1HDAC3
SCHEMBL4737264 0.79 HDAC6 (0.53) HDAC6HDAC8KDM5BHDAC1HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008061160-A1 USES OF SELECTIVE INHIBITORS OF HDAC8 FOR TREATMENT OF INFLAMMATORY CONDITIONS PHARMACYCLICS, INC. (US) 2008-05-22 WO claimed
WO-2007109178-A9 INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE PHARMACYCLICS INC (US) 2008-10-16 WO disclosed
WO-2007109178-A2 INDOLE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE PHARMACYCLICS, INC. (US) 2007-09-27 WO disclosed