SCHEMBL4736273

SCHEMBL4736273

COc1cc(C(=O)Nc2cc(C(=O)N3CCC(c4ccc(C#N)cc4)CC3)ccc2C)nc(OC)n1

nearest known ligand 0.61

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
FASN P49327 20/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4735032 0.82 FASN (0.66) FASN
SCHEMBL4786339 0.82 FASN (0.71) FASN
SCHEMBL4732219 0.81 FASN (0.73) FASN
SCHEMBL4736854 0.81 FASN (0.69) FASN
SCHEMBL4736481 0.81 FASN (0.74) FASN
SCHEMBL4734450 0.80 FASN (0.69) FASN
SCHEMBL4785694 0.80 FASN (0.67) FASN
SCHEMBL4736922 0.80 FASN (0.71) FASN
SCHEMBL4736229 0.80 FASN (0.69) FASN
SCHEMBL4785415 0.80 FASN (0.73) FASN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008059214-A1 BISAMLDE DERIVATIVES AND USE THEREOF AS FATTY ACID SYNTHASE INHIBITORS ASTRAZENECA AB (SE) 2008-05-22 WO disclosed