SCHEMBL4736313

Cc1ccc(C(=O)N2CCC(c3ccc(CC(=O)N(C)C)cc3)CC2)cc1NS(C)(=O)=O.Cc1ccc(C(=O)N2CCC(c3ccc(CC(N)=O)cc3)CC2)cc1NS(C)(=O)=O

nearest known ligand 0.49

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	FASN	P49327	18/20	0.49

▸	ALDH1A1	P00352	2/20	0.39

▸	MEN1	O00255	1/20	0.38

▸	LMNA	P02545	1/20	0.38

▸	CYP3A4	P08684	1/20	0.38

▸	GAA	P10253	1/20	0.38

▸	HPGD	P15428	1/20	0.38

▸	CYP2C19	P33261	1/20	0.38

▸	HTT	P42858	1/20	0.38

▸	KMT2A	Q03164	1/20	0.38

▸	SMN1; SMN2	Q16637	1/20	0.38

▸	NPSR1	Q6W5P4	1/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4180265	0.96	FASN (0.53)	FASN
SCHEMBL4174463	0.94	FASN (0.54)	FASNALDH1A1MEN1LMNACYP3A4
SCHEMBL4737299	0.87	FASN (0.46)	FASNALDH1A1MEN1LMNACYP3A4
SCHEMBL4180286	0.87	FASN (0.51)	FASN
SCHEMBL4190006	0.86	FASN (0.55)	FASNALDH1A1MEN1LMNACYP3A4
SCHEMBL4176497	0.85	FASN (0.58)	FASN
SCHEMBL4186690	0.84	FASN (0.54)	FASN
SCHEMBL4187269	0.84	FASN (0.57)	FASN
SCHEMBL4176216	0.84	FASN (0.57)	FASN
SCHEMBL4175298	0.84	FASN (0.59)	FASNALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2008075070-A1	SULFONAMIDE DERIVATIVES FOR THERAPEUTIC USE AS FATTY ACID SYNTHASE INHIBITORS	ASTRAZENECA AB (SE)	2008-06-26	—	—	WO	claimed