Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.71 |
| ▸ | BACE2 | Q9Y5Z0 | 12/20 | 0.71 |
| ▸ | CTSD | P07339 | 10/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4737368 | 0.99 | BACE1 (0.70) | BACE1BACE2CTSD | |
| SCHEMBL4737735 | 0.96 | BACE1 (0.77) | BACE1BACE2CTSD | |
| Hydrochloric Acid SCHEMBL4798064 | 0.95 | BACE1 (0.76) | BACE1BACE2CTSD | |
| SCHEMBL4518726 | 0.85 | BACE1 (0.70) | BACE1BACE2CTSD | |
| Acetic Acid SCHEMBL4734635 | 0.85 | BACE1 (0.63) | BACE1BACE2CTSD | |
| SCHEMBL8188914 | 0.85 | BACE1 (0.69) | BACE1BACE2CTSD | |
| SCHEMBL8189766 | 0.84 | BACE1 (0.73) | BACE1BACE2CTSD | |
| Hydrochloric Acid SCHEMBL5127622 | 0.84 | BACE1 (0.68) | BACE1BACE2CTSD | |
| Hydrochloric Acid SCHEMBL4736072 | 0.83 | BACE1 (0.72) | BACE1BACE2CTSD | |
| SCHEMBL3535101 | 0.83 | BACE1 (1.00) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008076044-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008076044-A1 | NOVEL 2-AMINO-5, 5-DIARYL-IMIDAZOL-4-ONES | ASTRAZENECA AB (SE) | 2008-06-26 | — | — | WO | disclosed |