Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4739051 | 0.78 | ADORA2A (0.48) | KDM4ELMNAKMT2AMAPTPOLB | |
| SCHEMBL4738561 | 0.78 | TSHR (0.48) | TSHRHSD17B10LMNAKMT2AMAPT | |
| SCHEMBL14147957 | 0.77 | ADORA2A (0.42) | TSHRKDM4ELMNAKMT2AMAPT | |
| SCHEMBL14147958 | 0.76 | SMN1; SMN2 (0.42) | TSHRKDM4EHSD17B10KMT2ATP53 | |
| SCHEMBL14147951 | 0.76 | ALOX5AP (0.44) | TSHRKDM4ELMNAMAPT | |
| SCHEMBL14147954 | 0.75 | ADORA2A (0.39) | TSHRKDM4EHSD17B10KMT2AMAPT | |
| SCHEMBL14147955 | 0.75 | ADORA2A (0.46) | KDM4EKMT2AMAPTTDP1 | |
| SCHEMBL14147950 | 0.74 | MEN1 (0.40) | KDM4ELMNAKMT2AMAPTMTOR | |
| SCHEMBL14147952 | 0.73 | BRAF (0.45) | KDM4ELMNAKMT2AMAPTPOLB | |
| SCHEMBL14147959 | 0.73 | MAPT (0.43) | TSHRKDM4EHSD17B10LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |
| WO-2008086158-A1 | BENZODIHYDROQUINAZOLINE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-17 | — | — | WO | disclosed |