SCHEMBL4736893

SCHEMBL4736893

COc1ccc(-c2ccc(NC(=O)Nc3ccc(N(C)C)cc3)cc2)c2c(N)onc12

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDR P35968 15/20 0.55
FLT3 P36888 15/20 0.55
FLT1 P17948 8/20 0.55
LCK P06239 5/20 0.55
LYN P07948 5/20 0.55
FLT4 P35916 5/20 0.55
BLK P51451 5/20 0.55
FYN P06241 4/20 0.55
AURKA O14965 4/20 0.55
ROCK2 O75116 4/20 0.55
RPS6KA5 O75582 4/20 0.55
NTRK1 P04629 4/20 0.55
RET P07949 4/20 0.55
FGFR1 P11362 4/20 0.55
FER P16591 4/20 0.55
RPS6KB1 P23443 4/20 0.55
FRK P42685 4/20 0.55
RPS6KA3 P51812 4/20 0.55
MAP4K2 Q12851 4/20 0.55
ROCK1 Q13464 4/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1384165 0.89 FLT3 (0.59) KDRFLT3FLT1LCKLYN
SCHEMBL4740457 0.86 FLT3 (0.60) KDRFLT3FLT1LCKLYN
SCHEMBL422817 0.86 KDR (0.74) KDRFLT3FLT1LCKLYN
SCHEMBL4738212 0.85 KDR (0.75) KDRFLT3FLT1LCKLYN
SCHEMBL4786668 0.83 KDR (0.76) KDRFLT3FLT1LCKLYN
SCHEMBL4738551 0.83 KDR (0.66) KDRFLT3FLT1LCKLYN
SCHEMBL4735281 0.83 KDR (0.65) KDRFLT3FLT1LCKLYN
SCHEMBL1379843 0.82 KDR (0.77) KDRFLT3FLT1LCKLYN
SCHEMBL1379867 0.82 KDR (0.77) KDRFLT3FLT1LCKLYN
SCHEMBL4735873 0.82 KDR (0.64) KDRFLT3FLT1LCKLYN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008080110-A1 METHODS FOR TREATING MACULAR EDEMA AND PATHOLOGIC OCULAR ANGIOGENESIS USING A NEUROPROTECTIVE AGENT AND A RECEPTOR TYROSINE KINASE INHIBITOR ALCON, INC. (CH) 2008-07-03 WO claimed
EP-1850839-A2 METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS ALCON INC. (CH) 2007-11-07 EP claimed
WO-2006091801-A2 METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS ALCON, INC. (CH) 2006-08-31 WO claimed
EP-1850839-A2 METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS ALCON INC. (CH) 2007-11-07 EP disclosed
WO-2006091801-A2 METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS ALCON, INC. (CH) 2006-08-31 WO disclosed