Sugi Predict

Sugi Predict / Compounds / SCHEMBL4737006

SCHEMBL4737006

SCHEMBL4737006

O=C(O)CNC(=O)c1c(O)nc(C2CCCCC2)n(-c2ccccc2)c1=O

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ EGLN1 Q9GZT9 13/20 0.52
▸ EGLN2 Q96KS0 2/20 0.47
▸ EGLN3 Q9H6Z9 2/20 0.47
▸ OGFOD1 Q8N543 1/20 0.47
▸ HIF1AN Q9NWT6 1/20 0.47
▸ DRD1 P21728 2/20 0.43
▸ DRD5 P21918 2/20 0.43
▸ SMN1; SMN2 Q16637 1/20 0.43
▸ APLNR P35414 1/20 0.43
▸ BBOX1 O75936 1/20 0.40
▸ ASPH Q12797 1/20 0.40
▸ KDM8 Q8N371 1/20 0.40
▸ OPRM1 P35372 1/20 0.40
▸ OPRD1 P41143 1/20 0.40
▸ OPRK1 P41145 1/20 0.40
▸ OGFRL1 Q5TC84 1/20 0.40
▸ LMNA P02545 1/20 0.40
▸ HTT P42858 1/20 0.39
▸ ALOX15 P16050 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4992285 0.91 EGLN1 (0.54) EGLN1EGLN2EGLN3OGFOD1HIF1AN
SCHEMBL4985569 0.91 EGLN1 (0.44) EGLN1EGLN2EGLN3OGFOD1HIF1AN
SCHEMBL4995811 0.90 HIF1A (0.47) EGLN1EGLN2EGLN3OGFOD1HIF1AN
SCHEMBL4992314 0.89 EGLN1 (0.44) EGLN1EGLN2EGLN3OGFOD1HIF1AN
SCHEMBL4991812 0.89 EGLN1 (0.44) EGLN1EGLN2EGLN3OGFOD1HIF1AN
SCHEMBL4738462 0.88 EGLN3 (0.49) EGLN1EGLN2EGLN3OGFOD1HIF1AN
SCHEMBL4994532 0.88 EGLN1 (0.43) EGLN1EGLN2EGLN3OGFOD1HIF1AN
SCHEMBL4992269 0.88 EGLN1 (0.45) EGLN1EGLN2EGLN3OGFOD1HIF1AN
SCHEMBL14123846 0.87 EGLN1 (0.44) EGLN1EGLN2EGLN3OGFOD1HIF1AN
SCHEMBL4995450 0.87 EGLN3 (0.43) EGLN1EGLN2EGLN3OGFOD1HIF1AN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008089051-A1 N-SUBSTITUTED GLYCINE DERIVATIVES: PROLYL HYDROXYLASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2008-07-24 — — WO claimed
US-20080171756-A1 N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors SMITHKLINE BEECHAM CORPORATION 2008-07-17 — — US claimed
WO-2008089051-A1 N-SUBSTITUTED GLYCINE DERIVATIVES: PROLYL HYDROXYLASE INHIBITORS SMITHKLINE BEECHAM CORPORATION (US) 2008-07-24 — — WO disclosed
US-20080171756-A1 N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors SMITHKLINE BEECHAM CORPORATION 2008-07-17 — — US disclosed
US-20080171756-A1 N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors SMITHKLINE BEECHAM CORPORATION 2008-07-17 — — US disclosed
US-20080171756-A1 N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors SMITHKLINE BEECHAM CORPORATION 2008-07-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080171756-A1 N-Substituted Glycine Derivatives: Prolyl Hydroxylase Inhibitors HIF1AN, EGLN2, EGLN3 EGLN1 5/4885EGLN2 2/4885EGLN3 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.