SCHEMBL4737069

SCHEMBL4737069

Cc1c(COc2ccc([C@H](CC(=O)O)c3nnnn3C)cc2)cccc1-c1cccc(Cl)c1

nearest known ligand 0.70

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 18/20 0.70
CD274 Q9NZQ7 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4734057 0.85 FFAR1 (0.78) FFAR1
SCHEMBL4734063 0.85 FFAR1 (0.78) FFAR1
SCHEMBL4738785 0.83 FFAR1 (0.88) FFAR1
SCHEMBL4733077 0.83 FFAR1 (1.00) FFAR1
SCHEMBL4733083 0.83 FFAR1 (1.00) FFAR1
SCHEMBL4738776 0.83 FFAR1 (0.88) FFAR1
SCHEMBL4736885 0.76 FFAR1 (0.56) FFAR1
SCHEMBL12021251 0.76 FFAR1 (0.87) FFAR1
SCHEMBL4767757 0.75 FFAR1 (0.59) FFAR1
SCHEMBL4736688 0.74 FFAR1 (0.67) FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1893582-A2 COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USE IN TREATING METABOLIC DISORDERS Amgen, Inc (US) 2008-03-05 EP claimed
WO-2006127503-A2 COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USE IN TREATING METABOLIC DISORDERS AMGEN INC (US) 2006-11-30 WO claimed
EP-1893582-A2 COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USE IN TREATING METABOLIC DISORDERS Amgen, Inc (US) 2008-03-05 EP disclosed
WO-2006127503-A2 COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THEIR USE IN TREATING METABOLIC DISORDERS AMGEN INC (US) 2006-11-30 WO disclosed