SCHEMBL4737306

Cc1ccc(C(=O)N2CCC(c3ccc(CNC(=O)C(C)(O)CC(C(=O)N(C)C)c4ccc(C5CCN(C(=O)c6ccc(C)c(NS(C)(=O)=O)c6)CC5)cc4)cc3)CC2)cc1NS(C)(=O)=O

nearest known ligand 0.43

Predicted protein targets (top 13)

	gene	UniProt	supporting neighbours	confidence
▸	FASN	P49327	13/20	0.43

▸	LMNA	P02545	2/20	0.37

▸	HPGD	P15428	2/20	0.37

▸	MEN1	O00255	1/20	0.37

▸	ALDH1A1	P00352	1/20	0.37

▸	CYP3A4	P08684	1/20	0.37

▸	GAA	P10253	1/20	0.37

▸	CYP2C19	P33261	1/20	0.37

▸	HTT	P42858	1/20	0.37

▸	KMT2A	Q03164	1/20	0.37

▸	SMN1; SMN2	Q16637	1/20	0.37

▸	NPSR1	Q6W5P4	1/20	0.37

▸	TRPV1	Q8NER1	1/20	0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4175623	0.86	FASN (0.51)	FASNLMNAHPGDMEN1ALDH1A1
SCHEMBL4737299	0.84	FASN (0.46)	FASNLMNAHPGDMEN1ALDH1A1
SCHEMBL4182773	0.80	FASN (0.54)	FASNLMNAHPGDMEN1ALDH1A1
SCHEMBL4187580	0.80	FASN (0.51)	FASNLMNAHPGDMEN1ALDH1A1
SCHEMBL4174452	0.80	FASN (0.53)	FASNLMNAHPGDMEN1ALDH1A1
SCHEMBL4172482	0.79	FASN (0.52)	FASNLMNAHPGDMEN1ALDH1A1
SCHEMBL4184678	0.79	FASN (0.52)	FASNLMNAHPGDMEN1ALDH1A1
SCHEMBL4175321	0.79	FASN (0.52)	FASNLMNAHPGDMEN1ALDH1A1
SCHEMBL4176863	0.79	FASN (0.55)	FASNLMNAHPGDMEN1ALDH1A1
SCHEMBL4168084	0.79	FASN (0.50)	FASN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2008075070-A1	SULFONAMIDE DERIVATIVES FOR THERAPEUTIC USE AS FATTY ACID SYNTHASE INHIBITORS	ASTRAZENECA AB (SE)	2008-06-26	—	—	WO	disclosed