Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 8/20 | 0.64 |
| ▸ | CHEK2 | O96017 | 7/20 | 0.64 |
| ▸ | JAK3 | P52333 | 5/20 | 0.62 |
| ▸ | AKT2 | P31751 | 2/20 | 0.62 |
| ▸ | GSK3B | P49841 | 2/20 | 0.62 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737158 | 0.83 | JAK3 (0.54) | JAK3AKT2GSK3BDOT1LKIT | |
| SCHEMBL4738959 | 0.83 | HRH4 (0.55) | CHEK1CHEK2JAK3AKT2GSK3B | |
| SCHEMBL21788682 | 0.80 | CHEK1 (0.70) | CHEK1CHEK2 | |
| SCHEMBL14162955 | 0.78 | JAK3 (0.49) | JAK3AKT2DOT1LJAK2 | |
| SCHEMBL13221971 | 0.78 | CHEK1 (1.00) | CHEK1CHEK2 | |
| SCHEMBL13221984 | 0.78 | CHEK1 (1.00) | CHEK1CHEK2 | |
| SCHEMBL3118976 | 0.78 | CHEK1 (1.00) | CHEK1CHEK2 | |
| SCHEMBL4127724 | 0.78 | DOT1L (0.73) | JAK3AKT2GSK3BDOT1LKIT | |
| SCHEMBL31499276 | 0.77 | JAK3 (1.00) | JAK3AKT2GSK3BDOT1LKIT | |
| SCHEMBL1333081 | 0.77 | JAK3 (1.00) | JAK3AKT2GSK3BDOT1LKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008075007-A1 | MORPHOLINO-SUBSTITUTED BICYCLOHETEROARYL COMPOUNDS AND THEIR USE AS ANTI CANCER AGENTS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008075007-A1 | MORPHOLINO-SUBSTITUTED BICYCLOHETEROARYL COMPOUNDS AND THEIR USE AS ANTI CANCER AGENTS | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2008-06-26 | — | — | WO | disclosed |