Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ11 | Q14654 | 7/20 | 0.47 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.47 |
| ▸ | ABCC8 | Q09428 | 1/20 | 0.47 |
| ▸ | KCNJ8 | Q15842 | 1/20 | 0.47 |
| ▸ | CTSV | O60911 | 3/20 | 0.44 |
| ▸ | CTSL | P07711 | 3/20 | 0.44 |
| ▸ | CTSB | P07858 | 3/20 | 0.44 |
| ▸ | CTSS | P25774 | 3/20 | 0.44 |
| ▸ | CTSK | P43235 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4678562 | 0.85 | KCNJ11 (0.54) | KCNJ11ABCC9ABCC8KCNJ8CTSV | |
| SCHEMBL4678565 | 0.85 | KCNJ11 (0.54) | KCNJ11ABCC9ABCC8KCNJ8CTSV | |
| SCHEMBL4678862 | 0.85 | KCNJ11 (0.51) | KCNJ11ABCC9ABCC8KCNJ8MAPT | |
| SCHEMBL4678860 | 0.85 | KCNJ11 (0.51) | KCNJ11ABCC9ABCC8KCNJ8MAPT | |
| SCHEMBL4679855 | 0.82 | KCNJ11 (0.70) | KCNJ11ABCC9ABCC8KCNJ8 | |
| SCHEMBL4679851 | 0.82 | KCNJ11 (0.70) | KCNJ11ABCC9ABCC8KCNJ8 | |
| SCHEMBL4681743 | 0.82 | KCNJ11 (0.69) | KCNJ11ABCC9ABCC8KCNJ8MEN1 | |
| SCHEMBL4679166 | 0.82 | KCNJ11 (0.69) | KCNJ11ABCC9ABCC8KCNJ8 | |
| SCHEMBL4681747 | 0.82 | KCNJ11 (0.69) | KCNJ11ABCC9ABCC8KCNJ8MEN1 | |
| SCHEMBL4679164 | 0.82 | KCNJ11 (0.69) | KCNJ11ABCC9ABCC8KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392655-B1 | POTASSIUM CHANNEL OPENERS | ABBOTT LAB (US) | 2008-07-16 | — | — | EP | disclosed |