Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738536 | 1.00 | BACE1 (0.53) | BACE1 | |
| SCHEMBL4737798 | 1.00 | BACE1 (0.53) | BACE1 | |
| SCHEMBL758008 | 1.00 | BACE1 (0.53) | BACE1 | |
| Hydrochloric Acid SCHEMBL758835 | 0.99 | BACE1 (0.52) | BACE1 | |
| SCHEMBL755069 | 0.95 | BACE1 (0.54) | BACE1 | |
| SCHEMBL757477 | 0.94 | BACE1 (0.53) | BACE1 | |
| SCHEMBL765610 | 0.94 | BACE1 (0.53) | BACE1 | |
| Hydrochloric Acid SCHEMBL761709 | 0.94 | BACE1 (0.53) | BACE1 | |
| SCHEMBL755639 | 0.94 | BACE1 (0.53) | BACE1 | |
| Hydrochloric Acid SCHEMBL755758 | 0.94 | BACE1 (0.52) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910364-A2 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Merck & Co., Inc. (US) | 2008-04-16 | — | — | EP | claimed |
| WO-2007011833-A2 | SPIROPIPERIDINE BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2007-01-25 | — | — | WO | claimed |