Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 16/20 | 0.52 |
| ▸ | HCRTR2 | O43614 | 14/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4738267 | 0.98 | HCRTR1 (0.54) | HCRTR1HCRTR2KDM4EALDH1A1HPGD | |
| SCHEMBL1398889 | 0.96 | HCRTR1 (0.57) | HCRTR1HCRTR2KDM4EALDH1A1HPGD | |
| SCHEMBL4743875 | 0.91 | HCRTR1 (0.53) | HCRTR1HCRTR2 | |
| SCHEMBL4739904 | 0.91 | HCRTR1 (0.53) | HCRTR1HCRTR2 | |
| SCHEMBL4743893 | 0.89 | HCRTR1 (0.52) | HCRTR1HCRTR2 | |
| SCHEMBL4738324 | 0.89 | HCRTR1 (0.55) | HCRTR1HCRTR2 | |
| SCHEMBL1398822 | 0.88 | HCRTR1 (0.67) | HCRTR1HCRTR2 | |
| SCHEMBL4787989 | 0.87 | HCRTR1 (0.66) | HCRTR1HCRTR2 | |
| SCHEMBL1398771 | 0.87 | HCRTR1 (0.52) | HCRTR1HCRTR2 | |
| SCHEMBL1398828 | 0.86 | HCRTR1 (0.58) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008087611-A2 | PYRROLIDINE- AND PIPERIDINE- BIS-AMIDE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-07-24 | — | — | WO | disclosed |