Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.62 |
| ▸ | KIT | P10721 | 12/20 | 0.62 |
| ▸ | FLT3 | P36888 | 11/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.59 |
| ▸ | FLT1 | P17948 | 4/20 | 0.55 |
| ▸ | TEK | Q02763 | 3/20 | 0.55 |
| ▸ | CSF1R | P07333 | 3/20 | 0.55 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.55 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.54 |
| ▸ | FLT4 | P35916 | 2/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.54 |
| ▸ | IKBKB | O14920 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.54 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | MARK3 | P27448 | 1/20 | 0.54 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4736486 | 0.93 | KDR (0.72) | KDRKITFLT3PDGFRBFLT1 | |
| SCHEMBL4737823 | 0.93 | KDR (0.70) | KDRKITFLT3PDGFRBFLT1 | |
| SCHEMBL1384952 | 0.86 | KDR (0.74) | KDRKITFLT3PDGFRBFLT1 | |
| SCHEMBL4735263 | 0.86 | KDR (0.70) | KDRKITFLT3PDGFRBFLT1 | |
| SCHEMBL5249583 | 0.85 | KDR (0.73) | KDRKITFLT3PDGFRBFLT1 | |
| SCHEMBL1382612 | 0.85 | KDR (0.68) | KDRKITFLT3PDGFRBFLT1 | |
| SCHEMBL1383101 | 0.84 | KDR (0.67) | KDRKITFLT3PDGFRBFLT1 | |
| SCHEMBL5362753 | 0.84 | KDR (0.55) | KDRKITFLT3PDGFRBFLT1 | |
| SCHEMBL1382188 | 0.84 | KDR (0.70) | KDRKITFLT3PDGFRBFLT1 | |
| SCHEMBL4736538 | 0.84 | KDR (0.72) | KDRKITFLT3PDGFRBFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008080110-A1 | METHODS FOR TREATING MACULAR EDEMA AND PATHOLOGIC OCULAR ANGIOGENESIS USING A NEUROPROTECTIVE AGENT AND A RECEPTOR TYROSINE KINASE INHIBITOR | ALCON, INC. (CH) | 2008-07-03 | — | — | WO | claimed |
| EP-1850839-A2 | METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS | ALCON INC. (CH) | 2007-11-07 | — | — | EP | claimed |
| WO-2006091801-A2 | METHODS FOR TREATING OCULAR ANGIOGENESIS, RETINAL EDEMA, RETINAL ISCHEMIA, AND DIABETIC RETINOPATHY USING SELECTIVE RTK INHIBITORS | ALCON, INC. (CH) | 2006-08-31 | — | — | WO | claimed |
| WO-2008080110-A1 | METHODS FOR TREATING MACULAR EDEMA AND PATHOLOGIC OCULAR ANGIOGENESIS USING A NEUROPROTECTIVE AGENT AND A RECEPTOR TYROSINE KINASE INHIBITOR | ALCON, INC. (CH) | 2008-07-03 | — | — | WO | disclosed |