SCHEMBL4739640

SCHEMBL4739640

CC(C)(C)OC(=O)Nc1cccc(C(=O)N2CCC(c3ccc(C#N)cc3)CC2)c1.CC(C)COC(=O)Nc1cc(C(=O)N2CCC(c3ccc(C#N)cc3)CC2)ccc1OC(F)(F)F

nearest known ligand 0.46

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
FASN P49327 20/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4734336 0.85 FASN (0.56) FASN
SCHEMBL4733791 0.80 FASN (0.49) FASN
SCHEMBL4734580 0.79 FASN (0.56) FASN
SCHEMBL4734864 0.79 FASN (0.61) FASN
SCHEMBL4203148 0.78 FASN (0.57) FASN
SCHEMBL4737935 0.78 FASN (0.56) FASN
SCHEMBL4738986 0.78 FASN (0.57) FASN
SCHEMBL4179936 0.76 FASN (0.62) FASN
SCHEMBL4173174 0.75 FASN (0.70) FASN
SCHEMBL4786113 0.74 FASN (0.54) FASN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008075077-A1 PIPERIDINE DERIVATIVES FOR THE TREATMENT OF OBESITY ASTRAZENECA AB (SE) 2008-06-26 WO claimed
WO-2008075077-A1 PIPERIDINE DERIVATIVES FOR THE TREATMENT OF OBESITY ASTRAZENECA AB (SE) 2008-06-26 WO disclosed