Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 19/20 | 0.66 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.66 |
| ▸ | PIK3CA | P42336 | 11/20 | 0.55 |
| ▸ | MAPK8 | P45983 | 9/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 9/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 9/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4739063 | 0.87 | MAPK1 (0.69) | MAPK1MAPK14PIK3CAMAPK8MAPK9 | |
| SCHEMBL5445419 | 0.85 | MAPK1 (0.77) | MAPK1MAPK14PIK3CAMAPK8MAPK9 | |
| SCHEMBL4736471 | 0.84 | MAPK1 (0.66) | MAPK1MAPK14PIK3CAMAPK8MAPK9 | |
| SCHEMBL14506694 | 0.82 | MAPK1 (0.74) | MAPK1MAPK14PIK3CAMAPK8MAPK9 | |
| SCHEMBL5463710 | 0.82 | MAPK1 (0.78) | MAPK1MAPK14PIK3CAMAPK8MAPK9 | |
| SCHEMBL4734471 | 0.81 | MAPK1 (0.64) | MAPK1MAPK14PIK3CAMAPK8MAPK9 | |
| SCHEMBL4735763 | 0.81 | MAPK1 (0.61) | MAPK1MAPK14PIK3CAMAPK8MAPK9 | |
| SCHEMBL4786556 | 0.81 | MAPK1 (0.67) | MAPK1MAPK14PIK3CAMAPK8MAPK9 | |
| SCHEMBL5455879 | 0.81 | MAPK1 (0.74) | MAPK1MAPK14PIK3CAMAPK8MAPK9 | |
| SCHEMBL16673870 | 0.81 | MAPK1 (0.67) | MAPK1MAPK14PIK3CAMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962854-B1 | PYRIDOPYRAZINE DERIVATIVES AND USE THEREOF AS MODULATORS OF THE SIGNAL TRANSDUCTION PATHS | TERNA ZENTARIS GMBH (DE) | 2015-05-06 | — | — | EP | claimed |
| EP-1636228-B1 | NOVEL PYRIDOPYRAZINES AND USE THEREOF AS KINASE MODULATORS | AETERNA ZENTARIS GMBH (DE) | 2008-10-22 | — | — | EP | claimed |