Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2021558 | 0.87 | BACE1 (0.37) | BACE1HDAC6 | |
| SCHEMBL4742409 | 0.83 | BACE1 (0.38) | BACE1 | |
| SCHEMBL4944316 | 0.81 | BACE1 (0.44) | BACE1 | |
| SCHEMBL14350445 | 0.80 | BACE1 (0.56) | BACE1 | |
| SCHEMBL2021556 | 0.80 | BACE1 (0.56) | BACE1 | |
| SCHEMBL2021554 | 0.80 | BACE1 (0.56) | BACE1 | |
| SCHEMBL12578732 | 0.80 | BACE1 (0.56) | BACE1 | |
| SCHEMBL12578561 | 0.80 | BACE1 (0.56) | BACE1 | |
| SCHEMBL2027884 | 0.80 | BACE1 (0.44) | BACE1 | |
| SCHEMBL4684615 | 0.79 | BACE1 (0.55) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740581-A4 | 2, 4, 6-SUBSTITUTED PYRIDYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO INC (US) | 2008-01-23 | — | — | EP | disclosed |
| EP-1740581-A1 | 2, 4, 6-SUBSTITUTED PYRIDYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER\"S DISEASE | Merck and Co., Inc. (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005103043-A1 | 2, 4, 6-SUBSTITUTED PYRIDYL DERIVATIVE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER’S DISEASE | MERCK & CO., INC. (US) | 2005-11-03 | — | — | WO | disclosed |