Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | USP1 | O94782 | 1/20 | 0.47 |
| ▸ | USP19 | O94966 | 1/20 | 0.47 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | GLA | P06280 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11246777 | 0.81 | IKBKB (0.58) | IKBKBMAPTNR4A2NOTUMKDM4E | |
| SCHEMBL5154427 | 0.81 | NR4A2 (0.68) | IKBKBMAPTNR4A2NOTUMKDM4E | |
| SCHEMBL15716531 | 0.79 | IKBKB (0.56) | IKBKBMAPTNOTUMKDM4EALDH1A1 | |
| SCHEMBL15716348 | 0.78 | MAPK13 (0.54) | MAPTNR4A2KDM4EALDH1A1HPGD | |
| SCHEMBL5154162 | 0.78 | NR4A2 (0.48) | IKBKBMAPTNR4A2KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL15716993 | 0.78 | IKBKB (0.54) | IKBKBMAPTNOTUMKDM4EALDH1A1 | |
| SCHEMBL5158055 | 0.78 | IKBKB (0.54) | IKBKBMAPTNOTUMKDM4EALDH1A1 | |
| SCHEMBL762311 | 0.77 | NR4A2 (0.62) | MAPTNR4A2KDM4EALDH1A1HPGD | |
| SCHEMBL2089928 | 0.75 | SMN1; SMN2 (0.50) | IKBKBMAPTNR4A2KDM4EALDH1A1 | |
| SCHEMBL2089931 | 0.75 | KDM4E (0.56) | MAPTKDM4EALDH1A1HPGDUSP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008090382-A1 | THIAZOLE AND OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PRION DISEASES, CANCER AND CONDITIONS OF THE CENTRAL NERVOUS SYSTEM AS WELL AS IN THE REGULATION OF STEM CELLS | THE UNIVERSITY OF SHEFFIELD (GB) | 2008-07-31 | — | — | WO | claimed |
| WO-2008090382-A1 | THIAZOLE AND OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PRION DISEASES, CANCER AND CONDITIONS OF THE CENTRAL NERVOUS SYSTEM AS WELL AS IN THE REGULATION OF STEM CELLS | THE UNIVERSITY OF SHEFFIELD (GB) | 2008-07-31 | — | — | WO | disclosed |
| WO-2008090382-A1 | THIAZOLE AND OXAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF PRION DISEASES, CANCER AND CONDITIONS OF THE CENTRAL NERVOUS SYSTEM AS WELL AS IN THE REGULATION OF STEM CELLS | THE UNIVERSITY OF SHEFFIELD (GB) | 2008-07-31 | — | — | WO | disclosed |