Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 14/20 | 0.60 |
| ▸ | PDK1 | Q15118 | 4/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.35 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.35 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4876524 | 0.77 | GPBAR1 (0.67) | GPBAR1PDK1 | |
| SCHEMBL4878795 | 0.77 | GPBAR1 (0.67) | GPBAR1PDK1 | |
| SCHEMBL4876511 | 0.77 | GPBAR1 (0.67) | GPBAR1PDK1 | |
| SCHEMBL4741994 | 0.76 | GPBAR1 (0.87) | GPBAR1 | |
| SCHEMBL4741905 | 0.75 | GPBAR1 (1.00) | GPBAR1 | |
| SCHEMBL4741992 | 0.71 | GPBAR1 (0.66) | GPBAR1 | |
| SCHEMBL14065463 | 0.71 | GPBAR1 (0.66) | GPBAR1 | |
| SCHEMBL4878801 | 0.67 | GPBAR1 (0.79) | GPBAR1 | |
| SCHEMBL4739227 | 0.67 | GPBAR1 (1.00) | GPBAR1 | |
| SCHEMBL4880271 | 0.65 | GPBAR1 (0.68) | GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008097976-A1 | HETEROCYCLIC MODULATORS OF TGR5 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2008-08-14 | — | — | WO | disclosed |