Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.56 |
| ▸ | EGFR | P00533 | 7/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.56 |
| ▸ | STK10 | O94804 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | YES1 | P07947 | 1/20 | 0.56 |
| ▸ | RET | P07949 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | BCR | P11274 | 1/20 | 0.56 |
| ▸ | FLT1 | P17948 | 1/20 | 0.56 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.56 |
| ▸ | WEE1 | P30291 | 1/20 | 0.56 |
| ▸ | ABL2 | P42684 | 1/20 | 0.56 |
| ▸ | NEK3 | P51956 | 1/20 | 0.56 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.56 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.56 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.56 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.56 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21801840 | 0.90 | KDR (0.70) | KDREGFRERBB2STK10MAP4K4 | |
| SCHEMBL4343000 | 0.89 | KDR (0.56) | KDREGFRERBB2STK10MAP4K4 | |
| SCHEMBL4737160 | 0.88 | KDR (0.62) | KDREGFRERBB2STK10MAP4K4 | |
| SCHEMBL20305684 | 0.83 | EGFR (0.54) | KDREGFRERBB2STK10MAP4K4 | |
| SCHEMBL4896590 | 0.81 | EGFR (0.83) | KDREGFRERBB2STK10MAP4K4 | |
| SCHEMBL3840840 | 0.81 | EGFR (0.83) | KDREGFRERBB2STK10MAP4K4 | |
| SCHEMBL1435666 | 0.80 | EGFR (0.79) | KDREGFRERBB2HDAC3HDAC4 | |
| SCHEMBL4342967 | 0.80 | EGFR (0.63) | KDREGFRERBB2STK10MAP4K4 | |
| SCHEMBL4739325 | 0.79 | HDAC3 (0.74) | KDREGFRERBB2HDAC3HDAC4 | |
| SCHEMBL4349463 | 0.77 | HDAC3 (0.64) | KDREGFRERBB2STK10MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008033747-A9 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS INC (MA) | 2008-07-24 | — | — | WO | disclosed |