SCHEMBL4742340

SCHEMBL4742340

COCc1ccccc1C1(N2CCN(c3ccncc3)CC2)C(=O)N(S(=O)(=O)c2cccc3cccnc23)c2ccc(Cl)cc21

nearest known ligand 0.71

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
AVPR1B P47901 20/20 0.71

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2891385 0.89 AVPR1B (0.86) AVPR1B
SCHEMBL2891438 0.89 AVPR1B (0.88) AVPR1B
SCHEMBL2892973 0.88 AVPR1B (0.71) AVPR1B
SCHEMBL2891451 0.86 AVPR1B (0.77) AVPR1B
SCHEMBL2888657 0.86 AVPR1B (0.79) AVPR1B
SCHEMBL2888573 0.85 AVPR1B (0.67) AVPR1B
SCHEMBL2885090 0.85 AVPR1B (0.75) AVPR1B
SCHEMBL2888888 0.85 AVPR1B (0.68) AVPR1B
SCHEMBL4090584 0.84 AVPR1B (0.72) AVPR1B
SCHEMBL2890479 0.84 AVPR1B (0.71) AVPR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8486931-B2 Substituted oxindole compounds ABBOTT GMBH & CO. KG (DE) 2013-07-16 US claimed
WO-2008107399-A1 SUBSTITUTED OXINDOLE COMPOUNDS ABBOTT GMBH & CO. KG (DE) 2008-09-12 WO disclosed