Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10238814 | 0.82 | CYP2C19 (0.49) | KDM4EKCNH2ALDH1A1MAPTHPGD | |
| SCHEMBL2256874 | 0.80 | KDM4E (0.46) | KDM4EKCNH2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL1658639 | 0.80 | KDM4E (0.42) | KDM4EKCNH2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL5383786 | 0.80 | KDM4E (0.42) | KDM4EKCNH2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3752508 | 0.80 | PLK1 (0.43) | KDM4EKCNH2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL13654189 | 0.80 | KDM4E (0.42) | KDM4EKCNH2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL15436171 | 0.79 | KCNH2 (0.39) | KDM4EKCNH2ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL793212 | 0.78 | CYP2C9 (0.48) | KDM4EKCNH2NPC1RAB9ACYP2C9 | |
| SCHEMBL20922749 | 0.77 | KCNA3 (0.45) | KDM4EKCNH2ALDH1A1MAPTCYP3A4 | |
| SCHEMBL5071044 | 0.77 | KDM4E (0.43) | KDM4EKCNH2ALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008104756-A1 | UREA DERIVATIVES AND THEIR THERAPEUTIC USE | SERENTIS LIMITED (GB) | 2008-09-04 | — | — | WO | disclosed |