SCHEMBL4742748

SCHEMBL4742748

O=C(CCCOCCN1CCN(Cc2cc3c(NCCc4ccccc4)ncnc3[nH]2)CC1)NO

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 12/20 0.57
HDAC2 Q92769 11/20 0.57
HDAC6 Q9UBN7 11/20 0.57
HDAC3 O15379 10/20 0.57
HDAC4 P56524 10/20 0.57
HDAC7 Q8WUI4 10/20 0.57
HDAC10 Q969S8 10/20 0.57
HDAC11 Q96DB2 10/20 0.57
HDAC8 Q9BY41 10/20 0.57
HDAC9 Q9UKV0 10/20 0.57
HDAC5 Q9UQL6 10/20 0.57
KDR P35968 8/20 0.57
ERBB2 P04626 5/20 0.57
EGFR P00533 3/20 0.57
AURKA O14965 3/20 0.40
MAPK1 P28482 1/20 0.40
SLC29A1 Q99808 1/20 0.39
AURKB Q96GD4 1/20 0.39
EHMT1 Q9H9B1 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4739325 0.89 HDAC3 (0.74) HDAC1HDAC2HDAC6HDAC3HDAC4
SCHEMBL4335650 0.88 HDAC3 (0.51) HDAC1HDAC2HDAC6HDAC3HDAC4
SCHEMBL4741282 0.86 HDAC3 (0.76) HDAC1HDAC2HDAC6HDAC3HDAC4
SCHEMBL4742757 0.84 HDAC3 (0.76) HDAC1HDAC2HDAC6HDAC3HDAC4
SCHEMBL4893504 0.84 HDAC3 (0.76) HDAC1HDAC2HDAC6HDAC3HDAC4
SCHEMBL4342967 0.81 EGFR (0.63) HDAC1HDAC2HDAC6HDAC3HDAC4
SCHEMBL14123543 0.81 HDAC3 (0.86) HDAC1HDAC2HDAC6HDAC3HDAC4
SCHEMBL14123578 0.79 HDAC3 (0.87) HDAC1HDAC2HDAC6HDAC3HDAC4
SCHEMBL14123613 0.78 HDAC3 (0.89) HDAC1HDAC2HDAC6HDAC3HDAC4
SCHEMBL14123617 0.78 HDAC3 (0.89) HDAC1HDAC2HDAC6HDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008033747-A9 MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS CURIS INC (MA) 2008-07-24 WO disclosed