Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | CPT2 | P23786 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5540263 | 0.95 | HMGCR (0.48) | HMGCRCHRM1TBXA2RADRA1AFFAR1 | |
| SCHEMBL11922837 | 0.90 | HMGCR (0.44) | HMGCRCHRM1TBXA2RADRA1AFFAR1 | |
| SCHEMBL15237487 | 0.86 | TDP1 (0.45) | HMGCRCHRM1TBXA2RADRA1AFFAR1 | |
| SCHEMBL31021331 | 0.85 | TDP1 (0.48) | HMGCRCHRM1TBXA2RADRA1AFFAR1 | |
| SCHEMBL2349178 | 0.80 | TDP1 (0.48) | HMGCRCHRM1TBXA2RADRA1AFFAR1 | |
| SCHEMBL544642 | 0.80 | HMGCR (0.61) | HMGCRCHRM1TBXA2RADRA1AFFAR1 | |
| SCHEMBL974936 | 0.79 | FFAR1 (0.65) | HMGCRCHRM1TBXA2RADRA1AFFAR1 | |
| SCHEMBL10776763 | 0.78 | TDP1 (0.52) | FFAR1CPT2TDP1TSHRHSD17B10 | |
| SCHEMBL18850502 | 0.78 | FFAR1 (0.47) | HMGCRCHRM1TBXA2RADRA1AFFAR1 | |
| SCHEMBL1419066 | 0.78 | HMGCR (0.52) | HMGCRCHRM1TBXA2RADRA1AFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008099019-A1 | 6-HYDROXY-DIBENZODIAZEPINONES USEFUL AS HEPATITIS C VIRUS INHIBITORS | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-08-21 | — | — | WO | disclosed |
| WO-2008099019-A1 | 6-HYDROXY-DIBENZODIAZEPINONES USEFUL AS HEPATITIS C VIRUS INHIBITORS | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-08-21 | — | — | WO | disclosed |