Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 7/20 | 0.51 |
| ▸ | CCR8 | P51685 | 7/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.51 |
| ▸ | ATM | Q13315 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4237240 | 0.76 | CCR8 (0.61) | CCR8KCNH2ALDH1A1 | |
| SCHEMBL4235552 | 0.75 | CCR8 (0.63) | CCR8KCNH2ALDH1A1 | |
| SCHEMBL14106876 | 0.74 | CCR8 (0.46) | CCR8KCNH2 | |
| Hydrochloric Acid SCHEMBL4230897 | 0.74 | CCR8 (0.62) | CCR8KCNH2ALDH1A1 | |
| SCHEMBL4744845 | 0.73 | CCR8 (0.50) | CCR8KCNH2 | |
| SCHEMBL4237721 | 0.71 | CCR8 (0.51) | CCR8KCNH2ALDH1A1 | |
| SCHEMBL29767426 | 0.70 | CXCR4 (0.69) | CXCR4ATMALDH1A1ACHE | |
| SCHEMBL4233223 | 0.70 | CCR8 (0.46) | CCR8KCNH2ALDH1A1 | |
| SCHEMBL4238533 | 0.69 | CCR8 (0.81) | CCR8KCNH2 | |
| SCHEMBL4235211 | 0.69 | CCR8 (0.54) | CCR8KCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008099165-A1 | PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATMENT OF CCR8 MEDIATED DISEASES | ASTRAZENECA AB (SE) | 2008-08-21 | — | — | WO | disclosed |