Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.39 |
| ▸ | STAMBP | O95630 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4739588 | 0.89 | ADORA2A (0.48) | ADORA2AADORA1HPGDSKDREPHX2 | |
| SCHEMBL14148289 | 0.84 | TRPV1 (0.49) | SMN1; SMN2TP53PSMD14STAMBPDGAT2 | |
| SCHEMBL4787180 | 0.76 | FLT1 (0.48) | ADORA2AADORA1SMN1; SMN2KDRTP53 | |
| SCHEMBL14147888 | 0.74 | TRPV1 (0.49) | SMN1; SMN2PSMD14STAMBPDGAT2 | |
| SCHEMBL1644237 | 0.71 | EGLN1 (0.46) | PSMD14 | |
| SCHEMBL269559 | 0.69 | SMN1; SMN2 (0.49) | ADORA2AADORA1SMN1; SMN2KDREPHX2 | |
| SCHEMBL263858 | 0.69 | SMN1; SMN2 (0.43) | ADORA2AADORA1SMN1; SMN2KDRDDR1 | |
| SCHEMBL14147908 | 0.68 | SCN9A (0.52) | ADORA2AADORA1KDRFLT1 | |
| SCHEMBL264360 | 0.68 | SMN1; SMN2 (0.48) | ADORA2AADORA1HPGDSSMN1; SMN2KDR | |
| SCHEMBL14147719 | 0.67 | TRPV1 (0.49) | ADORA2AHPGDSTP53PPARDPSMD14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008090434-A1 | SUBSTITUTED N-BICYCLICALKYL BICYCLIC CARBOXYAMIDE COMPOUNDS | PFIZER JAPAN INC. (JP) | 2008-07-31 | — | — | WO | claimed |
| WO-2008090434-A1 | SUBSTITUTED N-BICYCLICALKYL BICYCLIC CARBOXYAMIDE COMPOUNDS | PFIZER JAPAN INC. (JP) | 2008-07-31 | — | — | WO | disclosed |