Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 20/20 | 0.71 |
| ▸ | RPS6KB1 | P23443 | 17/20 | 0.71 |
| ▸ | AKT1 | P31749 | 17/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4744983 | 0.85 | PDPK1 (0.70) | PDPK1RPS6KB1AKT1 | |
| SCHEMBL4745581 | 0.85 | PDPK1 (0.85) | PDPK1RPS6KB1AKT1 | |
| SCHEMBL4741895 | 0.83 | PDPK1 (1.00) | PDPK1RPS6KB1AKT1 | |
| SCHEMBL4744791 | 0.82 | PDPK1 (0.90) | PDPK1RPS6KB1AKT1 | |
| SCHEMBL4741692 | 0.82 | PDPK1 (1.00) | PDPK1RPS6KB1AKT1 | |
| SCHEMBL4742816 | 0.82 | PDPK1 (1.00) | PDPK1RPS6KB1AKT1 | |
| SCHEMBL4741573 | 0.82 | PDPK1 (1.00) | PDPK1RPS6KB1AKT1 | |
| SCHEMBL4810187 | 0.82 | PDPK1 (0.81) | PDPK1RPS6KB1AKT1 | |
| SCHEMBL4745774 | 0.81 | PDPK1 (0.81) | PDPK1RPS6KB1AKT1 | |
| SCHEMBL4742079 | 0.81 | PDPK1 (0.80) | PDPK1RPS6KB1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008109613-A1 | BENZO[C][2,7]NAPHTHYRIDINE DERIVATIVES, AND THEIR USE AS KINASE INHIBITORS | WYETH (US) | 2008-09-12 | — | — | WO | disclosed |