Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17407620 | 0.87 | DPP4 (0.52) | IDO1DPP4TRPA1NR3C1PGR | |
| SCHEMBL14478271 | 0.82 | SLC6A2 (0.48) | HTR2AHTR2CHTR2BTAAR1MAOA | |
| SCHEMBL14478296 | 0.82 | SLC6A2 (0.48) | HTR2AHTR2CHTR2BTAAR1MAOA | |
| SCHEMBL17413330 | 0.82 | SLC6A2 (0.48) | HTR2AHTR2CHTR2BTAAR1MAOA | |
| SCHEMBL2623872 | 0.77 | IDO1 (0.41) | IDO1TRPA1NR3C1PGRNR3C2 | |
| SCHEMBL19737292 | 0.74 | IDO1 (0.40) | IDO1DPP4TRPA1NR3C1PGR | |
| SCHEMBL13814727 | 0.74 | IDO1 (0.36) | IDO1DPP4EPHX1SLC6A2SLC6A4 | |
| SCHEMBL4823652 | 0.74 | IDO1 (0.36) | IDO1DPP4TRPA1EPHX1 | |
| SCHEMBL4413267 | 0.73 | IDO1 (0.38) | IDO1TRPA1NR3C1PGRNR3C2 | |
| SCHEMBL9071082 | 0.73 | IDO1 (0.38) | IDO1TRPA1NR3C1PGRNR3C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008109613-A1 | BENZO[C][2,7]NAPHTHYRIDINE DERIVATIVES, AND THEIR USE AS KINASE INHIBITORS | WYETH (US) | 2008-09-12 | — | — | WO | disclosed |