SCHEMBL474594

SCHEMBL474594

C=CCI.[MgH2]

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13490 0.95
SCHEMBL5758677 0.95
Ammonia Solution, Strong SCHEMBL1923639 0.90
Iodide SCHEMBL11827015 0.90
SCHEMBL9450700 0.90
Phosphine SCHEMBL5861366 0.90
SCHEMBL2080760 0.90
Charcoal, Activated SCHEMBL4824381 0.90
SCHEMBL1053689 0.90
SCHEMBL9347802 0.90

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 126 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113999241-B Method for synthesizing cephalotaxine intermediate 甘肃中医药大学 2024-03-26 CN claimed
CN-115093313-B Multi-methyl substituted spiroindane derivative cyclopentadiene, rhodium complex, preparation method, intermediate and application thereof 中国科学院上海有机化学研究所 2023-08-11 CN claimed
CN-115093313-A Cyclopentadiene derived from multi-methyl substituted spiroindane, rhodium complex thereof, preparation method, intermediate and application 中国科学院上海有机化学研究所 2022-09-23 CN claimed
CN-113999241-A Method for synthesizing cephalotaxine intermediate 甘肃中医药大学 2022-02-01 CN claimed
CN-108976187-B Substituted benzofuran derivative, preparation thereof and application thereof in preparation of antitumor drugs 上海青东生物科技有限公司 2021-11-26 CN claimed
CN-111454133-A Synthesis method of eugenol 江西恒诚天然香料油有限公司 2020-07-28 CN claimed
CN-111454132-A Method for synthesizing eugenol 江西恒诚天然香料油有限公司 2020-07-28 CN claimed
CN-106946961-B A kind of synthetic method of tetraestrone 厦门欧瑞捷生物科技有限公司 2019-08-06 CN claimed
CN-102066002-B Original position olefin polymerization catalyst system PROMERUS, LLC (US) 2015-08-26 CN claimed
CN-102453174-B Catalyst and styrene polymerization method CHINA PETROLEUM & CHEMICAL 2013-02-27 CN claimed
CN-102453174-A Catalyst and styrene polymerization method CHINA PETROLEUM & CHEMICAL 2012-05-16 CN claimed
CN-102066002-A In situ olefin polymerization catalyst system PROMERUS LLC 2011-05-18 CN claimed
EP-1362860-B1 Method for producing tetrakis (fluoraryl)borate magnesium compound NIPPON CATALYTIC CHEM IND (JP) 2010-09-15 EP claimed
CN-101531569-A Method for synthesizing 2-methylisoborneol UNIV TONGJI 2009-09-16 CN claimed
US-7205441-B2 Method for producing tetrakis (fluoroaryl) borate-magnesium compound NIPPON SHOKUBAI CO., LTD. (JP) 2007-04-17 US claimed
US-20030216598-A1 Method for producing tetrakis ( fluoroaryl) borate-magnesium compound NIPPON SHOKUBAI CO., LTD. (JP) 2003-11-20 US claimed
EP-1362860-A1 Method for producing tetrakis (fluoroaryl) borate magnesium compound Nippon Shokubai Co., Ltd. (JP) 2003-11-19 EP claimed
US-5124481-A Synthesis of unsymmetric allyl-(alkyl) tellurides THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1992-06-23 US claimed
US-4506061-A COORDINATION CATALYST, RANDOM JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1985-03-19 US claimed
WO-2024157915-A1 COMPOSITION, GRIGNARD REAGENT, AND METHOD FOR PRODUCING COMPOSITION 株式会社クラレ 2024-08-02 WO disclosed
CN-118165188-A Active polymer microsphere and preparation method thereof based on active anionic polymerization induced self-assembly 清华大学 2024-06-11 CN disclosed
CN-113999241-B Method for synthesizing cephalotaxine intermediate 甘肃中医药大学 2024-03-26 CN disclosed
CN-114716616-B Active polymer microsphere and preparation method thereof 清华大学 2024-03-12 CN disclosed
CN-114644738-B Active nano emulsion and preparation method thereof 清华大学 2023-07-14 CN disclosed
CN-116082367-A Y6 type non-fullerene electron acceptor based on benzothiophene side chain and preparation and application thereof 广州市香港科大霍英东研究院 2023-05-09 CN disclosed
CN-115093313-A Cyclopentadiene derived from multi-methyl substituted spiroindane, rhodium complex thereof, preparation method, intermediate and application 中国科学院上海有机化学研究所 2022-09-23 CN disclosed
CN-114805414-A Method for synthesizing tetrafluoro aryl borate through continuous flow reaction 孟祥梅 2022-07-29 CN disclosed
CN-114716616-A Active polymer microsphere and preparation method thereof 清华大学 2022-07-08 CN disclosed
CN-114644738-A Active nano latex and preparation method thereof 清华大学 2022-06-21 CN disclosed
CN-113999241-A Method for synthesizing cephalotaxine intermediate 甘肃中医药大学 2022-02-01 CN disclosed
CN-108976187-B Substituted benzofuran derivative, preparation thereof and application thereof in preparation of antitumor drugs 上海青东生物科技有限公司 2021-11-26 CN disclosed
CN-108409678-B Process for producing tetrazolinone compound 住友化学株式会社 2021-04-27 CN disclosed
CN-112645388-A Recycling treatment method of magnesium-containing wastewater 浙江胡涂硅科技有限公司 2021-04-13 CN disclosed
CN-112573550-A Method for preparing magnesium-based flame retardant by utilizing Grignard wastewater 衢州学院 2021-03-30 CN disclosed
CN-112551772-A Resource treatment method for Grignard reaction wastewater 衢州学院 2021-03-26 CN disclosed
CN-108430463-B Improved synthesis of honokiol 高露洁-棕榄公司 2021-01-29 CN disclosed
EP-3364957-B1 IMPROVED SYNTHESIS OF HONOKIOL COLGATE PALMOLIVE CO (US) 2020-12-09 EP disclosed
CN-111454133-A Synthesis method of eugenol 江西恒诚天然香料油有限公司 2020-07-28 CN disclosed
CN-111454132-A Method for synthesizing eugenol 江西恒诚天然香料油有限公司 2020-07-28 CN disclosed
CN-109328199-B The manufacturing method of catalyst 宝理塑料株式会社 2019-10-18 CN disclosed
CN-106946961-B A kind of synthetic method of tetraestrone 厦门欧瑞捷生物科技有限公司 2019-08-06 CN disclosed
CN-105440051-B A kind of thiophene pyridine derivate for the treatment of tuberculosis 重庆医药工业研究院有限责任公司 2019-07-05 CN disclosed
CN-109328199-A The manufacturing method of catalyst 宝理塑料株式会社 2019-02-12 CN disclosed
CN-108976187-A A kind of substitution benzofuran derivatives and its preparation and application in preparation of anti-tumor drugs 孙青龑 2018-12-11 CN disclosed
CN-106132939-B Process for producing tetrazolinone compound 住友化学株式会社 2018-11-13 CN disclosed
EP-3364957-A1 IMPROVED SYNTHESIS OF HONOKIOL Colgate-Palmolive Company (US) 2018-08-29 EP disclosed
US-10053406-B2 Synthesis of honokiol COLGATE-PALMOLIVE COMPANY (US) 2018-08-21 US disclosed
CN-108409678-A The manufacturing method of Terazololine-one compound 住友化学株式会社 2018-08-17 CN disclosed
US-20180201779-A1 DEGRADABLE RESIN PELLET AND MOLDED PRODUCT USING SAME OH SEUNG GEUN (KR) 2018-07-19 US disclosed
CN-107849343-A A kind of degradable resin particle and utilize its products formed 吴承根 2018-03-27 CN disclosed
CN-107001522-A Polymerization catalyst composition and method of using the same 株式会社普利司通 2017-08-01 CN disclosed
WO-2017105985-A1 PREPARATION OF ISOHEXIDE-3,6-DICARBALDEHYDES AND ISOHEXIDE-3,6-DIMETHANAMINES ARCHER DANIELS MIDLAND COMPANY (US) 2017-06-22 WO disclosed
WO-2017070568-A1 IMPROVED SYNTHESIS OF HONOKIOL COLGATE-PALMOLIVE COMPANY (US) 2017-04-27 WO disclosed
US-20170113989-A1 SYNTHESIS OF HONOKIOL COLGATE-PALMOLIVE COMPANY 2017-04-27 US disclosed
CN-106132939-A Process for producing tetrazolinone compound 住友化学株式会社 2016-11-16 CN disclosed
US-9474758-B2 Thienopyrimidinedione derivatives as TRPA1 modulators GLENMARK PHARMACEUTICALS, S.A. (CH) 2016-10-25 US disclosed
CN-105541814-A Process for the preparation of compounds useful as inhibitors of SGLT JANSSEN PHARMACEUTICA NV 2016-05-04 CN disclosed
CN-102066002-B Original position olefin polymerization catalyst system PROMERUS, LLC (US) 2015-08-26 CN disclosed
US-20150150876-A1 THIENOPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS GLENMARK PHARMACEUTICALS, S.A. (CH) 2015-06-04 US disclosed
US-8987278-B2 Thienopyrimidinedione derivatives as TRPA1 modulators GLENMARK PHARMACEUTICALS S.A. (CH) 2015-03-24 US disclosed
EP-2634191-B1 Process for preparing derivatives of thienopyrimidinedione GLENMARK PHARMACEUTICALS SA (CH) 2014-12-24 EP disclosed
CN-102596979-B Processes and intermediates for the preparation of 1'-substituted carba-nucleoside analogs GILEAD SCIENCES INC 2014-12-10 CN disclosed
CN-103467439-A Process for the preparation of compounds useful as inhibitors of SGLT JANSSEN PHARMACEUTICA NV 2013-12-25 CN disclosed
US-20130289054-A1 THIENOPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS GLENMARK PHARMACEUTICALS S.A. (CH) 2013-10-31 US disclosed
EP-2634191-A1 Process for preparing derivatives of thienopyrimidinedione Glenmark Pharmaceuticals S.A. (CH) 2013-09-04 EP disclosed
US-8507503-B2 Thienopyrimidinedione derivatives as TRPA1 modulators GLENMARK PHARMACEUTICALS S.A. (CH) 2013-08-13 US disclosed
EP-2411396-B1 THIENOPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS GLENMARK PHARMACEUTICALS SA (CH) 2013-05-29 EP disclosed
CN-101263097-B Method for producing aromatic compound and aromatic compound obtained by the method IDEMITSU KOSAN CO 2013-05-01 CN disclosed
CN-102453174-B Catalyst and styrene polymerization method CHINA PETROLEUM & CHEMICAL 2013-02-27 CN disclosed
US-20120295924-A1 THIENOPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS GLENMARK PHARMACEUTICALS S.A. (CH) 2012-11-22 US disclosed
CN-102596979-A Processes and intermediates for the preparation of 1'-substituted carba-nucleoside analogs GILEAD SCIENCES INC 2012-07-18 CN disclosed
CN-102453174-A Catalyst and styrene polymerization method CHINA PETROLEUM & CHEMICAL 2012-05-16 CN disclosed
CN-102361877-A Thienopyrimidinedione derivatives as trpa1 modulators GLENMARK PHARMACEUTICALS SA 2012-02-22 CN disclosed
CN-102348635-A Process for producing organically modified carbon nanotube JAPAN SCIENCE & TECH AGENCY 2012-02-08 CN disclosed
EP-2411396-A2 THIENOPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS Glenmark Pharmaceuticals S.A. (CH) 2012-02-01 EP disclosed
US-8084645-B2 4-phenylamino-benzaldoxime derivatives and uses thereof as mitogen-activated protein kinase kinase (MEK) inhibitors CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2011-12-27 US disclosed
CN-102264714-A Process for preparing compounds useful as SGLT inhibitors 2011-11-30 CN disclosed
WO-2011114184-A1 AMIDES OF HETEROCYCLIC COMPOUNDS AS TRPA1 INHIBITORS GLENMARK PHARMACEUTICALS S.A. (CH) 2011-09-22 WO disclosed
CN-102066002-A In situ olefin polymerization catalyst system PROMERUS LLC 2011-05-18 CN disclosed
WO-2010109334-A2 THIENOPYRIMIDINEDIONE DERIVATIVES AS TRPA1 MODULATORS GLENMARK PHARMACEUTICALS, S.A. (CH) 2010-09-30 WO disclosed
EP-1362860-B1 Method for producing tetrakis (fluoraryl)borate magnesium compound NIPPON CATALYTIC CHEM IND (JP) 2010-09-15 EP disclosed
WO-2009078029-A2 AN IMPROVED PROCESS FOR THE PREPARATION OF TRANS 3,4- DIARYLCHROMAN AND THEIR DERIVATIVES COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) 2009-06-25 WO disclosed
US-20090069287-A1 SUBSTITUTED AZACYCLOALKANES USEFUL FOR TREATING CNS CONDITIONS PFIZER INC 2009-03-12 US disclosed
US-20090051281-A1 POLYMERIC COMPOUND FOR ORGANIC ELECTROLUMINESCENCE AND METHOD FOR PRODUCTION THEREOF IDEMITSU KOSAN CO., LTD (JP) 2009-02-26 US disclosed
EP-1985643-A1 POLYMERIC COMPOUND FOR ORGANIC ELECTROLUMINESCENCE AND METHOD FOR PRODUCTION THEREOF Idemitsu Kosan Co., Ltd. (JP) 2008-10-29 EP disclosed
CN-101263097-A Method for producing aromatic compound and aromatic compound obtained by the method IDEMITSU KOSAN CO (JP) 2008-09-10 CN disclosed
EP-1957448-A1 SUBSTITUTED AZACYCLOALKANES USEFUL FOR TREATING CNS CONDITIONS Pfizer Products Inc. (US) 2008-08-20 EP disclosed
CN-101203512-A Heterocyclic compounds DAIICHI SANKYO CO LTD (JP) 2008-06-18 CN disclosed
CN-101142204-A Improved method for Kumada coupling reaction HONEYWELL INT INC (US) 2008-03-12 CN disclosed
EP-1466918-B1 Novel bismuth compounds, process of producing the same, and process of producing a film TOSOH CORP (JP) 2007-06-13 EP disclosed
WO-2007060526-A1 SUBSTITUTED AZACYCLOALKANES USEFUL FOR TREATING CNS CONDITIONS PFIZER PRODUCTS INC. (US) 2007-05-31 WO disclosed
US-20070105859-A1 4-Phenylamino-benzaldoxime derivatives and uses thereof as mitogen-activated protein kinase kinase (mek) inhibitors CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2007-05-10 US disclosed
US-7205441-B2 Method for producing tetrakis (fluoroaryl) borate-magnesium compound NIPPON SHOKUBAI CO., LTD. (JP) 2007-04-17 US disclosed
EP-1460057-B1 PERFLUOROADAMANTYL ACRYLATE COMPOUND AND INTERMEDIATE THEREFOR IDEMITSU KOSAN CO (JP) 2006-12-13 EP disclosed
US-7084295-B2 Perfluoroadamantyl acrylate compound and intermediate therefor IDEMITSU KOSAN CO., LTD. (JP) 2006-08-01 US disclosed
EP-1674452-A1 NOVEL 4-PHENYLAMINO-BENZALDOXIME DERIVATIVE AND USE THEREOF AS MEK INHIBITOR CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) 2006-06-28 EP disclosed
US-6998488-B2 Process and intermediates for the preparation of 4-aryl piperidines MERCK & CO., INC. (US) 2006-02-14 US disclosed
US-6916944-B2 Bismuth compound, process of producing the same, and process of producing a film TOSOH CORPORATION (JP) 2005-07-12 US disclosed
US-20050131247-A1 Perfluoroadamantly acrylate compound and intermediate therefor IDEMITDU PETROCHEMICAL CO., LTD (JP) 2005-06-16 US disclosed
US-20040204483-A1 Novel bismuth compound, process of producing the same, and process of producing a film TOSOH CORPORATION 2004-10-14 US disclosed
EP-1466918-A1 Novel bismuth compounds, process of producing the same, and process of producing a film Tosoh Corporation (JP) 2004-10-13 EP disclosed
EP-1460057-A1 PERFLUOROADAMANTYL ACRYLATE COMPOUND AND INTERMEDIATE THEREFOR IDEMITSU PETROCHEMICAL CO., LTD. (JP) 2004-09-22 EP disclosed
US-20040181070-A1 Process and intermediates for the preparation of 4-aryl piperidines MERCK & CO., INC. 2004-09-16 US disclosed
WO-2004074333-A2 PROCESS FOR HOMO- OR COPOLYMERIZATIONOF CONJUGATED OLEFINES DOW GLOBAL TECHNOLOGIES INC. (US) 2004-09-02 WO disclosed
EP-0995753-B1 Method for manufacturing fluoroaryl magnesium halide NIPPON CATALYTIC CHEM IND (JP) 2004-02-18 EP disclosed
US-20040029917-A1 Benzosuberonylpiperdine compounds as analgesics GLAXOSMITHKLINE S.P.A. (IT) 2004-02-12 US disclosed
CN-1136187-C 1-amino-alkylcyclohexane NMDA receptor antagonists Ī�Ĺɷݹ�˾ 2004-01-28 CN disclosed
US-20030216598-A1 Method for producing tetrakis ( fluoroaryl) borate-magnesium compound NIPPON SHOKUBAI CO., LTD. (JP) 2003-11-20 US disclosed
EP-1362860-A1 Method for producing tetrakis (fluoroaryl) borate magnesium compound Nippon Shokubai Co., Ltd. (JP) 2003-11-19 EP disclosed
CN-1081641-C Carbapenem derivatives and antimicrobials MEIJI SEIKA KAISHA (JP) 2002-03-27 CN disclosed
US-6235222-B1 REACTING, IN SOLVENT CONTAINING CHAIN ETHER SOLVENT, HYDROCARBON MAGNESIUM HALIDE WITH FLUOROARYL HALIDE NIPPON SHOKUBAI CO., LTD. (JP) 2001-05-22 US disclosed
CN-1266423-A 1-amino-alkylcyclohexane NMDA receptor antagonists MERZ & CO GMBH & CO (DE) 2000-09-13 CN disclosed
EP-0995753-A2 Method for manufacturing fluoroaryl magnesium halide Nippon Shokubai Co., Ltd. (JP) 2000-04-26 EP disclosed
CN-1209810-A Carbapenem derivative and antibacterial agent MEIJI SEIKA KAISHA (JP) 1999-03-03 CN disclosed
US-5124481-A Synthesis of unsymmetric allyl-(alkyl) tellurides THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1992-06-23 US disclosed
US-5043477-A Methyl allyl telluride THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) 1991-08-27 US disclosed
US-4874861-A Pyridazinone derivatives, preparation thereof, and insecticidal, acaricidal, nematicidal, fungicidal compositions NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 1989-10-17 US disclosed
EP-0183212-A2 Pyridazinone derivatives, preparation thereof, and insecticidal, acaricidal, nematicidal, fungicidal compositions NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1986-06-04 EP disclosed
US-4569994-A Dibenzo[b,d]pyranyloxyaminopropanols PENNWALT CORPORATION 1986-02-11 US disclosed
US-4506061-A COORDINATION CATALYST, RANDOM JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1985-03-19 US disclosed
US-4356160-A CARRIED OUT IN AN ORGANIC SOLVENT AND AN ETHER WITH AN METAL CATALYSTS JAPAN EP RUBBER CO., LTD. (JP) 1982-10-26 US disclosed
US-4344855-A Process for the production of polyisocyanates which contain carbodiimide groups and which are stable in storage BAYER AKTIENGESELLSCHAFT (DE) 1982-08-17 US disclosed
US-4243674-A HYPOTENSIVE AGENTS; ANALGESICS; ANTISECRETORY AGENTS; ANTIBODY INHIBITORS, AND TRANQUILIZERS PFIZER INC. (US) 1981-01-06 US disclosed
US-4143139-A ANALGESICS, HYPOTENSIVES, IMMUNOSUPPRESSANTS, TRANQUILIZERS, ANTISECRETORY, ANTI-ANXIETY PFIZER INC. (US) 1979-03-06 US disclosed
US-4100110-A Isolongifolene Prins reaction compounds in perfumery BUSH BOAKE ALLEN LIMITED (GB) 1978-07-11 US disclosed
US-3947409-A 16-Alkyl-1,4,9(11)-pregnatrienes and 9,11-epoxides thereof MERCK & CO., INC. (US) 1976-03-30 US disclosed
US-3947409-A 16-Alkyl-1,4,9(11)-pregnatrienes and 9,11-epoxides thereof MERCK & CO., INC. (US) 1976-03-30 US disclosed