Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL342791 | 0.91 | RET (0.38) | KDM4EHSD17B10ALDH1A1RETHPGD | |
| SCHEMBL342790 | 0.91 | RET (0.38) | KDM4EHSD17B10ALDH1A1RETHPGD | |
| SCHEMBL343132 | 0.91 | RET (0.38) | KDM4EHSD17B10ALDH1A1RETHPGD | |
| SCHEMBL342794 | 0.86 | RET (0.41) | KDM4EHSD17B10MEN1ALDH1A1KMT2A | |
| SCHEMBL342792 | 0.86 | RET (0.41) | KDM4EHSD17B10MEN1ALDH1A1KMT2A | |
| SCHEMBL342793 | 0.86 | RET (0.41) | KDM4EHSD17B10MEN1ALDH1A1KMT2A | |
| SCHEMBL341757 | 0.85 | KDM4E (0.43) | KDM4EHSD17B10MEN1ALDH1A1KMT2A | |
| SCHEMBL341758 | 0.85 | KDM4E (0.43) | KDM4EHSD17B10MEN1ALDH1A1KMT2A | |
| SCHEMBL341759 | 0.85 | KDM4E (0.43) | KDM4EHSD17B10MEN1ALDH1A1KMT2A | |
| SCHEMBL473587 | 0.83 | KDM4E (0.64) | KDM4EHSD17B10MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411011-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | MSD K.K. (JP) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010111056-A1 | NOVEL AMINOPYRIDINE DERIVATIVES HAVING AURORA A SELECTIVE INHIBITORY ACTION | BANYU PHARMACEUTICAL CO., LTD. (JP) | 2010-09-30 | — | — | WO | disclosed |