Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GRK6 | P43250 | 2/20 | 0.37 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14041805 | 1.00 | MAPT (0.46) | MAPTMAPK1CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL14042382 | 1.00 | MAPT (0.46) | MAPTMAPK1CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL4746193 | 0.89 | MAPT (0.43) | MAPTMAPK1CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL4746197 | 0.89 | MAPT (0.43) | MAPTMAPK1CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL4746191 | 0.89 | MAPT (0.43) | MAPTMAPK1CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL13036670 | 0.88 | MAPT (0.46) | MAPTMAPK1CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL604219 | 0.88 | MAPT (0.46) | MAPTMAPK1CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL604220 | 0.88 | MAPT (0.46) | MAPTMAPK1CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL607051 | 0.86 | MAPT (0.47) | MAPTMAPK1CYP1A2CYP2C19CYP2C9 | |
| SCHEMBL10264194 | 0.86 | MAPT (0.47) | MAPTMAPK1CYP1A2CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008119715-A1 | 1- (1-CYCLOHEXYL-4-PIPERIDINYL) -1, 3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES WHICH HAVE ACTIVITY ON THE M1 RECEPTOR AND THEIR USE IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-10-09 | — | — | WO | disclosed |