Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 19/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 12/20 | 0.66 |
| ▸ | SCN5A | Q14524 | 13/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.44 |
| ▸ | GHSR | Q92847 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL840782 | 0.81 | SCN9A (1.00) | SCN9AKCNH2SCN5ASLC6A3GHSR | |
| SCHEMBL841447 | 0.80 | SCN9A (0.70) | SCN9AKCNH2SCN5ASLC6A3GHSR | |
| SCHEMBL841280 | 0.79 | SCN9A (0.57) | SCN9AKCNH2SCN5ASLC6A3GHSR | |
| SCHEMBL839807 | 0.79 | SCN9A (1.00) | SCN9AKCNH2SCN5ASLC6A3GHSR | |
| SCHEMBL841680 | 0.78 | SCN9A (0.62) | SCN9AKCNH2SCN5ASLC6A3GHSR | |
| SCHEMBL20873473 | 0.78 | SCN9A (0.42) | SCN9AKCNH2SCN5A | |
| SCHEMBL4747000 | 0.78 | SCN9A (0.42) | SCN9AKCNH2SCN5A | |
| SCHEMBL840991 | 0.77 | SCN9A (0.63) | SCN9AKCNH2SCN5ASLC6A3GHSR | |
| SCHEMBL840760 | 0.77 | SCN9A (0.72) | SCN9AKCNH2SCN5ASLC6A3GHSR | |
| SCHEMBL839786 | 0.77 | SCN9A (0.62) | SCN9AKCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130321-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR 5-HETEROCYCLYL-CHROMANE OR 8-HETEROCYCLYL-TETRAHYDRONAPHTALENE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| WO-2008130321-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR 5-HETEROCYCLYL-CHROMANE OR 8-HETEROCYCLYL-TETRAHYDRONAPHTALENE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |