Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 11/20 | 0.62 |
| ▸ | USP8 | P40818 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LDHA | P00338 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4249881 | 0.86 | EPHX2 (0.62) | EPHX2USP8KDM4ELDHAALDH1A1 | |
| SCHEMBL14507851 | 0.86 | EPHX2 (0.62) | EPHX2USP8KDM4ELDHAALDH1A1 | |
| SCHEMBL4252960 | 0.82 | EPHX2 (0.63) | EPHX2KDM4ELDHAALDH1A1POLB | |
| SCHEMBL4250848 | 0.79 | EPHX2 (0.62) | EPHX2USP8KDM4ELDHAALDH1A1 | |
| SCHEMBL4248700 | 0.78 | EPHX2 (0.91) | EPHX2L3MBTL1ALOX5TBXAS1SLC6A3 | |
| SCHEMBL4252762 | 0.78 | EPHX2 (0.53) | EPHX2USP8ALDH1A1POLBL3MBTL1 | |
| SCHEMBL4249803 | 0.77 | EPHX2 (0.63) | EPHX2USP8KDM4ELDHAALDH1A1 | |
| SCHEMBL4250817 | 0.77 | EPHX2 (0.89) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 | |
| SCHEMBL4246800 | 0.77 | EPHX2 (1.00) | EPHX2ALOX5TBXAS1SLC6A3SIGMAR1 | |
| SCHEMBL14507636 | 0.76 | EPHX2 (0.73) | EPHX2KDM4ELDHAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960367-A2 | SUBSTITUTED PYRAZOLE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007067836-A2 | SUBSTITUTED PYRAZOLE COMPOUNDS USEFUL AS SOLUBLE EPOXIDE HYDROLASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-06-14 | — | — | WO | disclosed |