Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 19/20 | 0.60 |
| ▸ | SCN5A | Q14524 | 17/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 14/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | GHSR | Q92847 | 1/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4747615 | 1.00 | SCN9A (0.60) | SCN9ASCN5AKCNH2SLC6A3GHSR | |
| SCHEMBL4788844 | 0.84 | SCN9A (0.44) | SCN9ASCN5AKCNH2SLC6A3GHSR | |
| SCHEMBL4788850 | 0.84 | SCN9A (0.44) | SCN9ASCN5AKCNH2SLC6A3GHSR | |
| SCHEMBL4750961 | 0.83 | SCN9A (0.65) | SCN9ASCN5AKCNH2SLC6A3GHSR | |
| SCHEMBL4749709 | 0.83 | SCN9A (0.65) | SCN9ASCN5AKCNH2SLC6A3GHSR | |
| SCHEMBL4786727 | 0.83 | SCN9A (0.65) | SCN9ASCN5AKCNH2SLC6A3GHSR | |
| SCHEMBL4786719 | 0.83 | SCN9A (0.65) | SCN9ASCN5AKCNH2SLC6A3GHSR | |
| SCHEMBL841192 | 0.78 | SCN9A (0.85) | SCN9ASCN5AKCNH2SLC6A3GHSR | |
| SCHEMBL841448 | 0.76 | SCN9A (0.88) | SCN9ASCN5AKCNH2SLC6A3GHSR | |
| SCHEMBL841352 | 0.76 | SCN9A (0.75) | SCN9ASCN5AKCNH2SLC6A3GHSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |