Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 9/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.75 |
| ▸ | SCN5A | Q14524 | 7/20 | 0.75 |
| ▸ | HTR2A | P28223 | 7/20 | 0.47 |
| ▸ | DRD3 | P35462 | 7/20 | 0.47 |
| ▸ | DRD2 | P14416 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4841770 | 0.91 | SCN9A (0.80) | SCN9AKCNH2SCN5AHTR2ADRD3 | |
| SCHEMBL4830458 | 0.91 | SCN9A (0.80) | SCN9AKCNH2SCN5AHTR2ADRD3 | |
| SCHEMBL4830465 | 0.91 | SCN9A (0.80) | SCN9AKCNH2SCN5AHTR2ADRD3 | |
| SCHEMBL4830436 | 0.87 | SCN9A (0.71) | SCN9AKCNH2SCN5AHTR2ADRD3 | |
| SCHEMBL8075533 | 0.87 | SCN9A (0.71) | SCN9AKCNH2SCN5AHTR2ADRD3 | |
| SCHEMBL4836383 | 0.87 | SCN9A (0.71) | SCN9AKCNH2SCN5AHTR2ADRD3 | |
| SCHEMBL4838340 | 0.86 | KCNH2 (0.70) | SCN9AKCNH2SCN5AHTR2ADRD3 | |
| SCHEMBL4838380 | 0.86 | KCNH2 (0.70) | SCN9AKCNH2SCN5AHTR2ADRD3 | |
| SCHEMBL4838400 | 0.86 | KCNH2 (0.70) | SCN9AKCNH2SCN5AHTR2ADRD3 | |
| SCHEMBL4842018 | 0.86 | KCNH2 (0.70) | SCN9AKCNH2SCN5AHTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130322-A1 | NOVEL 5-HETEROCYCLYL-CHROMANE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| WO-2008130322-A1 | NOVEL 5-HETEROCYCLYL-CHROMANE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |