Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | HSD17B1 | P14061 | 5/20 | 0.42 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4748369 | 1.00 | NPC1 (0.50) | NPC1HSD17B1HSD17B2CYP3A4CYP2C9 | |
| SCHEMBL4750633 | 1.00 | NPC1 (0.50) | NPC1HSD17B1HSD17B2CYP3A4CYP2C9 | |
| SCHEMBL381302 | 0.88 | NPC1 (0.62) | NPC1MAPTRAB9A | |
| SCHEMBL14351707 | 0.88 | NPC1 (0.62) | NPC1MAPTRAB9A | |
| Hydrochloric Acid SCHEMBL8894953 | 0.86 | NPC1 (0.60) | NPC1MAPTRAB9A | |
| SCHEMBL1338846 | 0.82 | NPC1 (0.51) | NPC1MAPTRAB9ACHRNB4CHRNA3 | |
| SCHEMBL7386839 | 0.79 | MAPT (0.47) | NPC1MAPTRAB9A | |
| SCHEMBL8550159 | 0.77 | NPC1 (0.62) | NPC1MAPTRAB9A | |
| SCHEMBL8307478 | 0.77 | NPC1 (0.62) | NPC1MAPTRAB9A | |
| SCHEMBL4751169 | 0.77 | NPC1 (0.43) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970303-B3 | SUBSTITUTED XANTHINES AND METHODS OF USE THEREOF | HYDRA BIOSCIENCES INC (US) | 2018-08-01 | — | — | EP | disclosed |
| WO-2008129129-A1 | HETEROCYCLIC PHENYL CARBAMATES AS NOVEL FAAH-INHIBITORS | KUOPION YLIOPISTO (FI) | 2008-10-30 | — | — | WO | disclosed |