SCHEMBL4748768

SCHEMBL4748768

O=C(Nc1cccc2[nH]ncc12)NC1CC2(CCC2)Oc2c(F)cc(F)cc21

nearest known ligand 0.62

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 20/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3323167 0.97 TRPV1 (0.61) TRPV1
SCHEMBL4788273 0.87 TRPV1 (0.70) TRPV1
SCHEMBL3323930 0.87 TRPV1 (0.70) TRPV1
SCHEMBL2358859 0.87 TRPV1 (0.78) TRPV1
SCHEMBL3321386 0.85 TRPV1 (0.77) TRPV1
SCHEMBL4786503 0.83 TRPV1 (0.66) TRPV1
SCHEMBL619280 0.83 TRPV1 (0.62) TRPV1
SCHEMBL3322897 0.83 TRPV1 (0.56) TRPV1
SCHEMBL3321468 0.82 TRPV1 (0.65) TRPV1
SCHEMBL2364953 0.82 TRPV1 (0.62) TRPV1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008110863-A1 INDAZOLE DERIVATIVES AND THEIR USE AS VANILLOID RECEPTOR LIGANDS GLENMARK PHARMACEUTICALS S.A. (US) 2008-09-18 WO claimed
WO-2008110863-A1 INDAZOLE DERIVATIVES AND THEIR USE AS VANILLOID RECEPTOR LIGANDS GLENMARK PHARMACEUTICALS S.A. (US) 2008-09-18 WO disclosed