⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13826336 | 0.88 | — | — | |
| SCHEMBL22044790 | 0.85 | DPP4 (0.36) | — | |
| SCHEMBL21363994 | 0.85 | DPP4 (0.36) | — | |
| SCHEMBL5258960 | 0.85 | DPP4 (0.36) | — | |
| SCHEMBL5260452 | 0.85 | DPP4 (0.36) | — | |
| SCHEMBL23764033 | 0.81 | GRIN2D (0.33) | — | |
| SCHEMBL22142926 | 0.81 | OPRL1 (0.36) | — | |
| SCHEMBL20715149 | 0.79 | CHRM2 (0.32) | — | |
| SCHEMBL1691932 | 0.79 | GRIN2D (0.32) | — | |
| SCHEMBL25105659 | 0.77 | KDM4E (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116731046-B | High-activity HPK1 kinase inhibitor | 杭州阿诺生物医药科技有限公司 | 2025-06-03 | — | — | CN | disclosed |
| CN-114555565-B | Nitrogen-containing heterocyclic compound, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2024-03-05 | — | — | CN | disclosed |
| US-20230399327-A1 | HIGH ACTIVITY HPK1 KINASE INHIBITOR | ADLAI NORTYE BIOPHARMA CO., LTD. (CN) | 2023-12-14 | — | — | US | disclosed |
| CN-117024445-A | Compounds for preparing HPK1 kinase inhibitor and synthesis method thereof | 杭州阿诺生物医药科技有限公司 | 2023-11-10 | — | — | CN | disclosed |
| CN-116731046-A | High-activity HPK1 kinase inhibitor | 杭州阿诺生物医药科技有限公司 | 2023-09-12 | — | — | CN | disclosed |
| CN-116685585-A | High-activity HPK1 kinase inhibitor | 杭州阿诺生物医药科技有限公司 | 2023-09-01 | — | — | CN | disclosed |
| CN-114555565-A | Nitrogen-containing heterocyclic compound, preparation method and application thereof | 四川科伦博泰生物医药股份有限公司 | 2022-05-27 | — | — | CN | disclosed |
| WO-2022089398-A1 | HIGH ACTIVITY HPK1 KINASE INHIBITOR | 杭州阿诺生物医药科技有限公司 | 2022-05-05 | — | — | WO | disclosed |
| WO-2021114691-A1 | NITROGEN-CONTAINING RING-FUSED COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF | 四川科伦博泰生物医药股份有限公司 | 2021-06-17 | — | — | WO | disclosed |
| US-10815246-B2 | Thailanstatin analogs | PH PHARMA CO., LTD. (KR) | 2020-10-27 | — | — | US | disclosed |
| US-20190233430-A1 | THAILANSTATIN ANALOGS | PH PHARMA CO., LTD. (KR) | 2019-08-01 | — | — | US | disclosed |
| WO-2015095953-A1 | SULFONAMIDE-CONTAINING LINKAGE SYSTEMS FOR DRUG CONJUGATES | THE CENTRE FOR DRUG RESEARCH AND DEVELOPMENT (CA) | 2015-07-02 | — | — | WO | disclosed |
| US-20120115845-A1 | THERAPEUTIC AGENTS | ALLEN JACK MCQUEEN (GB) | 2012-05-10 | — | — | US | disclosed |
| US-20110124621-A1 | BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2011-05-26 | — | — | US | disclosed |
| US-20090186870-A1 | Therapeutic Agents - 802 | ASTRAZENECA AB (SE) | 2009-07-23 | — | — | US | disclosed |
| WO-2009047558-A1 | BENZOTHIAZOLES AS GHRELIN RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2009-04-16 | — | — | WO | disclosed |