Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 7/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | EED | O75530 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.30 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3745707 | 0.87 | DPP4 (0.45) | DPP4DPP8DPP9FFAR1AURKA | |
| SCHEMBL3745703 | 0.87 | DPP4 (0.45) | DPP4DPP8DPP9FFAR1AURKA | |
| SCHEMBL3745710 | 0.87 | DPP4 (0.45) | DPP4DPP8DPP9FFAR1AURKA | |
| SCHEMBL3747993 | 0.75 | DPP4 (0.54) | DPP4DPP8DPP9DPP7KCNH2 | |
| SCHEMBL3746364 | 0.75 | DPP4 (0.49) | DPP4DPP8DPP9DPP7KCNH2 | |
| SCHEMBL3747985 | 0.75 | DPP4 (0.54) | DPP4DPP8DPP9DPP7KCNH2 | |
| SCHEMBL3746362 | 0.75 | DPP4 (0.49) | DPP4DPP8DPP9DPP7KCNH2 | |
| SCHEMBL3747988 | 0.75 | DPP4 (0.54) | DPP4DPP8DPP9DPP7KCNH2 | |
| SCHEMBL3746369 | 0.75 | DPP4 (0.49) | DPP4DPP8DPP9DPP7KCNH2 | |
| SCHEMBL3748074 | 0.73 | DPP4 (0.47) | DPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919854-A2 | PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | ABBOTT LABORATORIES (US) | 2008-05-14 | — | — | EP | disclosed |
| WO-2007027651-A2 | PHARMACEUTICAL COMPOSITIONS AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-IV (DPP-IV) | ABBOTT LABORATORIES (US) | 2007-03-08 | — | — | WO | disclosed |