Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 11/20 | 0.60 |
| ▸ | JAK3 | P52333 | 8/20 | 0.59 |
| ▸ | NTRK1 | P04629 | 8/20 | 0.44 |
| ▸ | FLT3 | P36888 | 3/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | MUSK | O15146 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.42 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 2/20 | 0.41 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.41 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14672478 | 1.00 | JAK2 (0.60) | JAK2JAK3NTRK1FLT3LCK | |
| SCHEMBL14676792 | 0.83 | JAK2 (0.51) | JAK2JAK3NTRK1FLT3LCK | |
| SCHEMBL14676793 | 0.83 | JAK2 (0.51) | JAK2JAK3NTRK1FLT3LCK | |
| SCHEMBL13313087 | 0.81 | AURKA (0.52) | NTRK1RETCSF1RAURKAFLT1 | |
| SCHEMBL3557473 | 0.81 | AURKA (0.52) | NTRK1RETCSF1RAURKAFLT1 | |
| SCHEMBL3515072 | 0.81 | AURKA (0.52) | NTRK1RETCSF1RAURKAFLT1 | |
| SCHEMBL4984208 | 0.80 | JAK2 (0.50) | JAK2JAK3NTRK1FLT3LCK | |
| SCHEMBL4984204 | 0.80 | JAK2 (0.50) | JAK2JAK3NTRK1FLT3LCK | |
| SCHEMBL14672541 | 0.78 | JAK2 (0.47) | JAK2JAK3NTRK1FLT3LCK | |
| SCHEMBL14672540 | 0.78 | JAK2 (0.47) | JAK2JAK3NTRK1FLT3LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008117050-A1 | PYRAZOLYL-AMINO-SUBSTITUTED PYRAZINES AND THEIR USE FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2008-10-02 | — | — | WO | disclosed |