Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | CLK1 | P49759 | 2/20 | 0.57 |
| ▸ | PARP1 | P09874 | 2/20 | 0.55 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.50 |
| ▸ | MEF2D | Q14814 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | RORC | P51449 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4749567 | 1.00 | MAPT (0.63) | MAPTKDM4ELMNASMN1; SMN2MAPK1 | |
| SCHEMBL4749569 | 1.00 | MAPT (0.63) | MAPTKDM4ELMNASMN1; SMN2MAPK1 | |
| SCHEMBL4749615 | 0.89 | PARP1 (0.58) | MAPTKDM4ELMNASMN1; SMN2MAPK1 | |
| SCHEMBL4749605 | 0.89 | PARP1 (0.58) | MAPTKDM4ELMNASMN1; SMN2MAPK1 | |
| SCHEMBL4749611 | 0.89 | PARP1 (0.58) | MAPTKDM4ELMNASMN1; SMN2MAPK1 | |
| SCHEMBL4749909 | 0.87 | PARP1 (0.58) | MAPTKDM4ELMNASMN1; SMN2MAPK1 | |
| SCHEMBL4749906 | 0.87 | PARP1 (0.58) | MAPTKDM4ELMNASMN1; SMN2MAPK1 | |
| SCHEMBL4749905 | 0.87 | PARP1 (0.58) | MAPTKDM4ELMNASMN1; SMN2MAPK1 | |
| SCHEMBL4749873 | 0.85 | KMT2A (0.61) | MAPTKDM4ELMNASMN1; SMN2MAPK1 | |
| SCHEMBL4749867 | 0.85 | KMT2A (0.61) | MAPTKDM4ELMNASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | claimed |
| WO-2008124000-A2 | THIAZOLE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR COMPOUNDS | LIGAND PHARMACEUTICALS INCORPORATED (US) | 2008-10-16 | — | — | WO | disclosed |