SCHEMBL4750207

SCHEMBL4750207

Brc1ccc(C#Cc2ccccn2)cc1

nearest known ligand 0.81

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 1/20 0.53
ERN1 O75460 1/20 0.49
GRM5 P41594 6/20 0.49
KCNH2 Q12809 2/20 0.47
CYP1A2 P05177 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30214469 1.00 FFAR1 (0.53) FFAR1ERN1GRM5KCNH2CYP1A2
SCHEMBL30822819 0.90 FFAR1 (0.46) FFAR1ERN1GRM5KCNH2
SCHEMBL30214468 0.84 FFAR1 (0.58) FFAR1GRM5KCNH2CYP1A2
SCHEMBL1809895 0.84 FFAR1 (0.58) FFAR1GRM5KCNH2CYP1A2
Hydrochloric Acid SCHEMBL19668206 0.82 FFAR1 (0.57) FFAR1GRM5KCNH2CYP1A2
SCHEMBL352291 0.81 GRM5 (0.65) GRM5KCNH2CYP1A2
SCHEMBL5569770 0.81 GRM5 (0.53) FFAR1ERN1GRM5KCNH2CYP1A2
SCHEMBL28950042 0.81 GRM5 (0.56) FFAR1ERN1GRM5KCNH2
SCHEMBL14061855 0.81 GRM5 (0.53) FFAR1ERN1GRM5KCNH2
SCHEMBL3391907 0.81 MAPT (0.57) FFAR1ERN1GRM5KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115677740-A Preparation method of N, O-boron difluoride complex 华南理工大学 2023-02-03 CN disclosed
CN-102249831-B New method for synthesizing 1,2,3-triaryl naphthalene derivatives UNIV BEIJING CHEMICAL 2015-04-08 CN disclosed
CN-102249831-A New method for synthesizing 1,2,3-triaryl naphthalene derivatives UNIV BEIJING CHEMICAL 2011-11-23 CN disclosed
WO-2008125599-A1 2-CARBOXY THIOPHENE DERIVATIVES AS ANTI-VIRAL AGENTS SMITHKLINE BEECHAM CORPORATION (US) 2008-10-23 WO disclosed