Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | UBE2N | P61088 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 6/20 | 0.54 |
| ▸ | TEK | Q02763 | 6/20 | 0.54 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | AURKA | O14965 | 3/20 | 0.48 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.48 |
| ▸ | JAK3 | P52333 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4535149 | 0.90 | KDM4E (0.61) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL6749286 | 0.90 | KDM4E (0.61) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL4697230 | 0.86 | KDM4E (0.67) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL4530280 | 0.86 | KDM4E (0.67) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL6750779 | 0.86 | KDM4E (0.54) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL4525163 | 0.86 | KDM4E (0.54) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL4527280 | 0.86 | KDM4E (0.56) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL6749275 | 0.86 | KDM4E (0.56) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL4530804 | 0.85 | KDM4E (0.64) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 | |
| SCHEMBL4697914 | 0.84 | KDM4E (0.63) | KDM4EALDH1A1HPGDUBE2NSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008131858-A2 | USE OF ACYCLICALLY SUBSTITUTED FUROPYRIMIDINE DERIVATIVES FOR TREATING PULMONARY ARTERIAL HYPERTONIA | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-11-06 | — | — | WO | disclosed |