Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP46A1 | Q9Y6A2 | 12/20 | 0.74 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | MTTP | P55157 | 3/20 | 0.51 |
| ▸ | PKLR | P30613 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14849013 | 0.85 | CYP46A1 (1.00) | CYP46A1AVPR1ACYP3A4CYP2C19CYP2C8 | |
| SCHEMBL14848962 | 0.80 | CYP46A1 (0.84) | CYP46A1AVPR1ACYP3A4CYP2C19CYP2C8 | |
| SCHEMBL14849067 | 0.79 | CYP46A1 (0.80) | CYP46A1AVPR1ACYP3A4CYP2C19CYP2C8 | |
| SCHEMBL22218935 | 0.78 | CYP46A1 (0.78) | CYP46A1AVPR1ACYP3A4CYP2C19CYP2C8 | |
| SCHEMBL14848966 | 0.77 | CYP46A1 (0.79) | CYP46A1AVPR1ACYP3A4CYP2C19CYP2C8 | |
| SCHEMBL594974 | 0.77 | KCNH2 (0.54) | MTTPTSHRRECQL | |
| SCHEMBL14849060 | 0.76 | CYP46A1 (1.00) | CYP46A1AVPR1ACYP3A4CYP2C19CYP2C8 | |
| SCHEMBL14849016 | 0.76 | CYP46A1 (0.85) | CYP46A1AVPR1ACYP3A4CYP2C19CYP2C8 | |
| SCHEMBL14214938 | 0.76 | TSHR (0.57) | MTTPTSHRRECQL | |
| SCHEMBL14840778 | 0.75 | CYP46A1 (1.00) | CYP46A1AVPR1ACYP3A4CYP2C19CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008134547-A1 | METHODS OF USING HYDROXYCYCLOHEXANE AND HYDROXYPIPERIDINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-11-06 | — | — | WO | claimed |
| WO-2008134547-A1 | METHODS OF USING HYDROXYCYCLOHEXANE AND HYDROXYPIPERIDINE COMPOUNDS IN TREATING SODIUM CHANNEL-MEDIATED DISEASES OR CONDITIONS | XENON PHARMACEUTICALS INC. (CA) | 2008-11-06 | — | — | WO | disclosed |