Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 15/20 | 0.82 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.72 |
| ▸ | ABL1 | P00519 | 2/20 | 0.61 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.61 |
| ▸ | EGFR | P00533 | 2/20 | 0.61 |
| ▸ | FYN | P06241 | 2/20 | 0.61 |
| ▸ | HCK | P08631 | 2/20 | 0.61 |
| ▸ | SRC | P12931 | 2/20 | 0.61 |
| ▸ | JAK3 | P52333 | 2/20 | 0.61 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.61 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.60 |
| ▸ | YES1 | P07947 | 1/20 | 0.60 |
| ▸ | LYN | P07948 | 1/20 | 0.60 |
| ▸ | FGR | P09769 | 1/20 | 0.60 |
| ▸ | KIT | P10721 | 1/20 | 0.60 |
| ▸ | BCR | P11274 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4754942 | 0.92 | MAPK14 (0.73) | LCKMAPK14ABL1MAPK13EGFR | |
| SCHEMBL773817 | 0.90 | LCK (1.00) | LCKMAPK14ABL1MAPK13EGFR | |
| SCHEMBL20530782 | 0.87 | LCK (0.82) | LCKMAPK14ABL1MAPK13EGFR | |
| SCHEMBL773705 | 0.85 | MAPK14 (0.82) | LCKMAPK14ABL1MAPK13EGFR | |
| SCHEMBL30608761 | 0.84 | LCK (0.73) | LCKMAPK14ABL1MAPK13EGFR | |
| SCHEMBL29074216 | 0.84 | LCK (0.73) | LCKMAPK14ABL1MAPK13EGFR | |
| SCHEMBL773145 | 0.84 | LCK (1.00) | LCKMAPK14ABL1MAPK13EGFR | |
| SCHEMBL774701 | 0.84 | MAPK14 (1.00) | LCKMAPK14ABL1MAPK13EGFR | |
| SCHEMBL13982223 | 0.84 | LCK (0.74) | LCKMAPK14ABL1MAPK13EGFR | |
| SCHEMBL775159 | 0.84 | MAPK14 (0.79) | LCKMAPK14ABL1MAPK13EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008150446-A1 | INHIBITORS OF PROTEIN KINASES | LIANG CONGXIN (US) | 2008-12-11 | — | — | WO | disclosed |
| WO-2008150446-A1 | INHIBITORS OF PROTEIN KINASES | LIANG CONGXIN (US) | 2008-12-11 | — | — | WO | disclosed |