Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 2/20 | 0.54 |
| ▸ | TRPC3 | Q13507 | 3/20 | 0.48 |
| ▸ | ORAI1 | Q96D31 | 3/20 | 0.47 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.44 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19692283 | 0.84 | TRPC3 (0.48) | PDPK1TRPC3ORAI1TRPC1STIM1 | |
| SCHEMBL537716 | 0.84 | PDPK1 (0.57) | PDPK1PTGS1PTGS2TGFBR1 | |
| SCHEMBL7318446 | 0.83 | ORAI1 (0.74) | TRPC3ORAI1TRPC1STIM1TP53 | |
| SCHEMBL7326377 | 0.83 | ORAI1 (0.74) | TRPC3ORAI1TRPC1STIM1TP53 | |
| SCHEMBL18865550 | 0.83 | SLC34A1 (0.44) | PDPK1TRPC3KDM4EPTGS1PTGS2 | |
| Hydrochloric Acid SCHEMBL31546273 | 0.83 | PDPK1 (0.56) | PDPK1PTGS1PTGS2TGFBR1 | |
| SCHEMBL31625278 | 0.83 | PDPK1 (0.53) | PDPK1PTGS1PTGS2TGFBR1 | |
| SCHEMBL18865866 | 0.83 | PDPK1 (0.53) | PDPK1TRPC3ORAI1STIM1KDM4E | |
| SCHEMBL18865526 | 0.83 | PDPK1 (0.53) | PDPK1PTGS1PTGS2TGFBR1 | |
| SCHEMBL7320721 | 0.81 | PDPK1 (0.42) | PDPK1TRPC3ORAI1TRPC1STIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008148836-A1 | COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-12-11 | — | — | WO | disclosed |
| WO-2008148836-A1 | COMPOUNDS WHICH POTENTIATE AMPA RECEPTOR AND USES THEREOF IN MEDICINE | GLAXO GROUP LIMITED (GB) | 2008-12-11 | — | — | WO | disclosed |