Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | HTR7 | P34969 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL265656 | 0.86 | CYP3A4 (0.59) | TP53MAPTKMT2AMEN1USP2 | |
| SCHEMBL264154 | 0.79 | CYP3A4 (0.57) | TP53MAPTKMT2AMEN1USP2 | |
| SCHEMBL263914 | 0.76 | MAPT (0.61) | MAPTKMT2AMEN1USP2ALDH1A1 | |
| SCHEMBL263619 | 0.76 | MAPT (0.61) | MAPTKMT2AMEN1USP2ALDH1A1 | |
| SCHEMBL18955633 | 0.76 | POLB (0.62) | TP53MAPTKMT2AMEN1USP2 | |
| SCHEMBL263156 | 0.75 | CYP3A4 (0.58) | TP53MAPTKMT2AMEN1USP2 | |
| SCHEMBL17770691 | 0.74 | HTT (0.73) | KMT2AMEN1USP2ALDH1A1TSHR | |
| SCHEMBL14022753 | 0.74 | KMT2A (0.56) | TP53MAPTKMT2AMEN1USP2 | |
| SCHEMBL263964 | 0.74 | SMN1; SMN2 (0.61) | TP53KMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL264173 | 0.73 | CYP3A4 (0.57) | MAPTKMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008138126-A1 | BICYCLIC PYRIMIDINE DERIVATIVES AS CALCIUM CHANNEL BLOCKERS | NEUROMED PHARMACEUTICALS LTD. (CA) | 2008-11-20 | — | — | WO | claimed |