Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 14/20 | 0.70 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.70 |
| ▸ | HRH2 | P25021 | 1/20 | 0.70 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1775555 | 0.86 | HRH4 (0.65) | HRH4HRH3HRH2KDRALDH1A1 | |
| SCHEMBL1774550 | 0.83 | HRH4 (1.00) | HRH4HRH3HRH2KDR | |
| SCHEMBL1776779 | 0.82 | HRH4 (0.79) | HRH4HRH3HRH2KDRCYP1A2 | |
| SCHEMBL1774487 | 0.80 | HRH4 (0.72) | HRH4HRH3HRH2KDRALDH1A1 | |
| SCHEMBL1774562 | 0.80 | HRH4 (0.68) | HRH4HRH3HRH2KDRALDH1A1 | |
| SCHEMBL1773934 | 0.80 | HRH4 (0.68) | HRH4HRH3HRH2KDR | |
| SCHEMBL1775001 | 0.80 | HRH4 (1.00) | HRH4HRH3HRH2KDRCYP1A2 | |
| SCHEMBL1774691 | 0.77 | HRH4 (0.67) | HRH4HRH3HRH2KDR | |
| SCHEMBL1775220 | 0.76 | HRH4 (1.00) | HRH4HRH3HRH2KDR | |
| SCHEMBL1774962 | 0.75 | HRH4 (0.67) | HRH4HRH3HRH2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966162-A2 | PYRIMIDINE DERIVATIVES | Pfizer Limited (GB) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007072163-A2 | PYRIMIDINE DERIVATIVES | PFIZER LIMITED (GB) | 2007-06-28 | — | — | WO | disclosed |