Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | UBE2N | P61088 | 1/20 | 0.51 |
| ▸ | TNK2 | Q07912 | 9/20 | 0.51 |
| ▸ | LCK | P06239 | 7/20 | 0.49 |
| ▸ | KDR | P35968 | 4/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.49 |
| ▸ | SRC | P12931 | 2/20 | 0.49 |
| ▸ | ZAP70 | P43403 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4698145 | 0.95 | TNK2 (0.49) | KDM4EALDH1A1HPGDSMN1; SMN2UBE2N | |
| SCHEMBL1786593 | 0.91 | TNK2 (0.48) | KDM4EALDH1A1HPGDSMN1; SMN2UBE2N | |
| SCHEMBL1787327 | 0.91 | TNK2 (0.48) | KDM4EALDH1A1HPGDSMN1; SMN2UBE2N | |
| SCHEMBL12607170 | 0.91 | TNK2 (0.48) | KDM4EALDH1A1HPGDSMN1; SMN2UBE2N | |
| SCHEMBL1785467 | 0.91 | TNK2 (0.48) | KDM4EALDH1A1HPGDSMN1; SMN2UBE2N | |
| SCHEMBL12607137 | 0.89 | TNK2 (0.49) | KDM4EALDH1A1HPGDSMN1; SMN2UBE2N | |
| SCHEMBL4750471 | 0.89 | TNK2 (0.47) | KDM4EALDH1A1HPGDSMN1; SMN2UBE2N | |
| SCHEMBL12607061 | 0.89 | TNK2 (0.47) | KDM4EALDH1A1HPGDSMN1; SMN2UBE2N | |
| SCHEMBL1787960 | 0.88 | TNK2 (0.48) | KDM4EALDH1A1HPGDSMN1; SMN2UBE2N | |
| SCHEMBL12607216 | 0.87 | TNK2 (0.45) | KDM4EALDH1A1HPGDSMN1; SMN2UBE2N |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008131859-A2 | USE OF CYCLICALLY SUBSTITUTED FUROPYRIMIDINE DERIVATIVES FOR TREATING PULMONARY ARTERIAL HYPERTONIA | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2008-11-06 | — | — | WO | disclosed |
| EP-1966218-A1 | NOVEL, CYCLIC SUBSTITUTED FUROPYRIMIDINE DERIVATIVES AND USE THEREOF FOR TREATING CARDIOVASCULAR DISEASES | Bayer HealthCare AG (DE) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007079861-A1 | NOVEL, CYCLIC SUBSTITUTED FUROPYRIMIDINE DERIVATIVES AND USE THEREOF FOR TREATING CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2007-07-19 | — | — | WO | disclosed |