Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 19/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.73 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3052824 | 1.00 | HRH3 (1.00) | HRH3KCNH2DRD2DRD3 | |
| SCHEMBL3052826 | 1.00 | HRH3 (1.00) | HRH3KCNH2DRD2DRD3 | |
| SCHEMBL3053249 | 0.91 | HRH3 (1.00) | HRH3KCNH2DRD2DRD3 | |
| SCHEMBL3060601 | 0.89 | HRH3 (1.00) | HRH3KCNH2DRD2DRD3 | |
| SCHEMBL3057565 | 0.88 | HRH3 (1.00) | HRH3KCNH2DRD2DRD3 | |
| SCHEMBL3067508 | 0.88 | HRH3 (1.00) | HRH3KCNH2DRD2DRD3 | |
| SCHEMBL3065741 | 0.84 | HRH3 (1.00) | HRH3KCNH2 | |
| SCHEMBL3055918 | 0.84 | HRH3 (1.00) | HRH3KCNH2 | |
| SCHEMBL3063591 | 0.84 | HRH3 (1.00) | HRH3KCNH2 | |
| SCHEMBL3058268 | 0.81 | HRH3 (1.00) | HRH3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001885-A2 | OCTAHYDRO-PYRROLO[3,4-B]PYRROLE DERIVATIVES | Abbott Laboratories (US) | 2008-12-17 | — | — | EP | claimed |
| WO-2007100990-A2 | OCTAHYDRO-PYRROLO[3,4-B] PYRROLE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTOR LIGANDS | ABBOTT LABORATORIES (US) | 2007-09-07 | — | — | WO | claimed |